Development of Novel Palladacycles for Synthesis Optimization of Drug Candidates
| dc.contributor.author | Gray, Hailey | |
| dc.date.accessioned | 2024-03-16T17:41:29Z | |
| dc.date.available | 2024-03-16T17:41:29Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Direct alkenylation and arylation reactions have been developed as a simpler synthetic pathway to access alkenylarene derivatives as they are important scaffolds in biologically active compounds. The goal of this research is the development of functionalized tri-tert-butyl phosphine palladacycle catalysts to undergo C-H functionalization for the synthesis of drug scaffolds. In this research, we developed functionalized tri-tert-butyl phosphine palladacycles for three novel transformations. During the first project, we improved the synthetic pathway of an anti-cancer drug candidate by incorporating a pyridine derivative into the palladacycle structure. In the second project, those same catalysts were used in the regioselective alkenylation of thiazoles. There are multiple examples where thiazole cores are functionalized at different positions in drug candidates. We have also used High Throughput Experimentation (HTE) to study the versatility of our catalysts in the C-H functionalization of cyclopropanes. These are common scaffolds in anti-HIV and anti-RSV drugs. | |
| dc.description.reviewstatus | Reviewed | |
| dc.description.scholarlevel | Undergraduate | |
| dc.description.sponsorship | Jamie Cassels Undergraduate Research Awards (JCURA) | |
| dc.identifier.uri | https://hdl.handle.net/1828/16164 | |
| dc.language.iso | en | |
| dc.publisher | University of Victoria | |
| dc.subject | palladacycle | |
| dc.subject | high-throughput | |
| dc.subject | direct arylation | |
| dc.subject | reaction optimization | |
| dc.title | Development of Novel Palladacycles for Synthesis Optimization of Drug Candidates | |
| dc.type | Poster |