Natural Biomaterials and Their Use as Bioinks for Printing Tissues
Date
2021
Authors
Benwood, Claire
Chrenek, Josie
Kirsch, Rebecca L.
Masri, Nadia Z.
Richards, Hannah
Teetzen, Kyra
Willerth, Stephanie M.
Journal Title
Journal ISSN
Volume Title
Publisher
Bioengineering
Abstract
The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natural bioinks. This paper reviews natural bioinks and their properties and functions in hard and soft tissue engineering applications. It discusses agarose, alginate, cellulose, chitosan, collagen, decellularized extracellular matrix, dextran, fibrin, gelatin, gellan gum, hyaluronic acid, Matrigel, and silk. Multi-component bioinks are considered as a way to address the shortfalls of individual biomaterials. The mechanical, rheological, and cross-linking properties along with the cytocompatibility, cell viability, and printability of the bioinks are detailed as well. Future avenues for research into natural bioinks are then presented.
Description
Keywords
bioink, 3D bioprinting, biomaterials, tissue engineering, regenerative medicine
Citation
Benwood, C., Chrenek, J., Kirsch, R. L., Masri, N. Z., Richards, H., Teetzen, K., & Willerth, S. M. (2021). Natural Biomaterials and Their Use as Bioinks for Printing Tissues. Bioengineering, 8(2), 1-19. https://doi.org/10.3390/bioengineering8020027.