Cavity optical spring sensing for single molecules

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dc.contributor.authorYu, Wenyan
dc.contributor.supervisorLu, Tao
dc.date.accessioned2017-02-28T16:37:08Z
dc.date.available2017-02-28T16:37:08Z
dc.date.copyright2017en_US
dc.date.issued2017-02-28
dc.degree.departmentDepartment of Electrical and Computer Engineeringen_US
dc.degree.levelDoctor of Philosophy Ph.D.en_US
dc.description.abstractThis thesis investigated single nanoparticle/molecule detections using a whispering gallery mode (WGM) microcavity, with focuses on sensing with the cavity optomechanical oscillation (OMO). The high quality (Q) factor and small mode volume properties of a WGM microcavity make it possible to establish a strong intracavity power density with a small amount of input optical power. Such a high optical power density exerts a radiation pressure that is sufficient to push the cavity wall moving outward. The dynamic interaction between the optical field and the mechanical motion eventually results in a regenerative mechanical oscillation of the WGM cavity, which is termed as the optomechanical oscillation. With a high Q spherical microcavity, the observation of OMO in heavy water is reported. To the best knowledge of the author, this is the first demonstration of the cavity OMO in an aqueous environment. Furthermore, by utilizing the properties of reactive sensing, cavity OMO, and optical spring effect, we demonstrated a new sensing mechanism that improves the WGM microcavity sensing resolution by several orders of magnitude. Finally, we conducted the demonstration of in-vitro molecule sensing by detecting single bindings of the 66 kDa Bovine Serum Albumin (BSA) protein molecules at a signal-to-noise ratio of 16.8.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationCavity Optomechanical Spring Sensing of Single Molecules Wenyan Yu, Wei C. Jiang, Qiang Lin, and Tao Lu Nature Communications 7, 12311 (2016)en_US
dc.identifier.bibliographicCitationWhispering Gallery Microcavity Nanosensor with In-Line Interferometer Steven Herchak, Wenyan Yu, Wu-Sheng Lu, and Tao Lu Biosensors Journal 4, 122 (2015)en_US
dc.identifier.bibliographicCitationCoherent Optomechanical Oscillation of a Silica Microsphere in an Aqueous Environment Wenyan Yu, Wei C. Jiang, Qiang Lin, and Tao Lu Optics Express Vol. 22, 21421 (2014)en_US
dc.identifier.bibliographicCitationImplementation of a Reference Interferometer for Nanodetection Serge Vincent, Wenyan Yu, and Tao Lu Journal of Visualized Experiments (86), e51133 (2014)en_US
dc.identifier.urihttp://hdl.handle.net/1828/7819
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectMicro-optical devicesen_US
dc.subjectOptomechanicsen_US
dc.subjectResonatorsen_US
dc.titleCavity optical spring sensing for single moleculesen_US
dc.typeThesisen_US

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