Rhythmic arm cycling training improves walking and interlimb integrity in chronic stroke

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dc.contributor.authorKaupp, Chelsea
dc.contributor.supervisorZehr, E. Paul
dc.date.accessioned2018-12-24T20:06:32Z
dc.date.available2018-12-24T20:06:32Z
dc.date.copyright2018en_US
dc.date.issued2018-12-24
dc.degree.departmentProgram: Neuroscienceen_US
dc.degree.levelMaster of Science M.Sc.en_US
dc.description.abstractTraining locomotor pattern generating networks (CPGs) with body weight supported treadmill training or through arm and leg cycling improves walking in chronic stroke. These outcomes are presumed to result from enhanced interlimb connectivity and CPG function. The extent to which rhythmic arm training activates interlimb CPG networks for locomotion remains unclear and was assessed by studying chronic stroke participants before and after 5-weeks of arm cycling training. Strength was assessed bilaterally via maximal voluntary isometric contractions in the legs and hands. Muscle activation during arm cycling and transfer to treadmill walking were assessed in the more affected (MA) and less affected (LA) sides via surface electromyography. Changes to interlimb coupling during rhythmic movement were evaluated using modulation of cutaneous reflexes elicited by electrical stimulation of the superficial radial nerve at the wrist. Bilateral soleus stretch reflexes were elicited at rest and during 1Hz arm cycling. Clinical function tests assessed walking, balance and motor function. Results show significant changes in function and neurophysiological integrity. Training increased bilateral grip strength, force during MA plantarflexion and muscle activation. ‘Normalization’ of cutaneous reflex modulation was found during arm cycling. There was enhanced activity in the dorsiflexor muscles on the MA side during swing phase of walking. Enhanced interlimb coupling was shown by increased modulation of MA soleus stretch reflexes amplitudes during arm cycling after training. Clinical evaluations showed enhanced walking ability and balance. These results are consistent with training-induced changes in CPG function and interlimb connectivity and underscore the need for arm training in the functional rehabilitation of walking after neurotrauma.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationKaupp, C., Pearcey, G.E.P., Klarner, T., Sun, Y., Cullen, H., Barss, T.S., Zehr, E.P.. (2017) Rhythmic arm cycling training improves walking and neurophysiological integrity in chronic stroke: the arms can give legs a helping hand in rehabilitation. Journal of Neurophysiology, 119:1095-1112en_US
dc.identifier.urihttp://hdl.handle.net/1828/10462
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectStrokeen_US
dc.subjectChronic Strokeen_US
dc.subjectWalkingen_US
dc.subjectArm Cyclingen_US
dc.subjectTraining Induced Plasticityen_US
dc.subjectRehabilitationen_US
dc.titleRhythmic arm cycling training improves walking and interlimb integrity in chronic strokeen_US
dc.typeThesisen_US

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