Drugs through Bugs: Expression of Naglu-­‐PTD4 in Spodoptera frugiperda

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dc.contributor.authorAshmead, Rhea
dc.date.accessioned2016-04-27T21:32:43Z
dc.date.available2016-04-27T21:32:43Z
dc.date.copyright2016en_US
dc.date.issued2016-04-27
dc.description.abstractMucopolysaccharidosis IIIB (MPS IIIB) is a rare metabolic disorder that is caused by a deficiency in the lysosomal hydrolase α-N-acetylglucosaminidase (Naglu). The deficient activity of this enzyme results in the cytotoxic accumulation of heparan sulfate in the lysosome. Patients with this disorder experience progressive central nervous system degeneration and a significantly shortened life span. Presently, enzyme replacement therapy is an ineffective treatment for MPS IIIB due to the inability of exogenous Naglu to permeate the blood-brain barrier. This project uses the Sf9 insect cell system to express human recombinant Naglu fused to a synthetic protein transduction domain with the intent to facilitate the delivery of Naglu across the blood-brain barrier. The overall goal of this project is to establish a large-scale, economical system for the production of human recombinant Naglu that has the potential to be successfully used for enzyme replacement therapy to treat MPS IIIB.en_US
dc.description.reviewstatusUnrevieweden_US
dc.description.scholarlevelUndergraduateen_US
dc.description.sponsorshipJamie Cassels Undergraduate Research Awarden_US
dc.identifier.urihttp://hdl.handle.net/1828/7217
dc.language.isoenen_US
dc.subjectSanfilippo Syndromeen_US
dc.subjectMucopolysaccharidosisen_US
dc.subjectα-N-acetylglucosaminidaseen_US
dc.subjectChoy Laben_US
dc.titleDrugs through Bugs: Expression of Naglu-­‐PTD4 in Spodoptera frugiperdaen_US
dc.typePosteren_US

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