C. elegans as a model organism to study female reproductive health

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dc.contributor.authorAthar, Faria
dc.contributor.authorTempleman, Nicole M
dc.date.accessioned2023-01-28T17:15:14Z
dc.date.available2023-01-28T17:15:14Z
dc.date.copyright2022en_US
dc.date.issued2022-04
dc.description.abstractFemale reproductive health has been historically understudied and underfunded. Here, we present the advantages of using a free-living nematode, Caenorhabditis elegans, as an animal system to study fundamental aspects of female reproductive health. C. elegans is a powerful high-throughput model organism that shares key genetic and physiological similarities with humans. In this review, we highlight areas of pressing medical and biological importance in the 21st century within the context of female reproductive health. These include the decline in female reproductive capacity with increasing chronological age, reproductive dysfunction arising from toxic environmental insults, and cancers of the reproductive system. C. elegans has been instrumental in uncovering mechanistic insights underlying these processes, and has been valuable for developing and testing therapeutics to combat them. Adopting a convenient model organism such as C. elegans for studying reproductive health will encourage further research into this field, and broaden opportunities for making advancements into evolutionarily conserved mechanisms that control reproductive function.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipCanada Research Chairs Program; Michael Smith Foundation for Health Researchen_US
dc.identifier.citationAthar F, Templeman NM. C. elegans as a model organism to study female reproductive health. Comp Biochem Physiol A Mol Integr Physiol. 2022 Apr;266:111152.en_US
dc.identifier.otherPMID: 35032657
dc.identifier.otherdoi: 10.1016/j.cbpa.2022.111152
dc.identifier.urihttp://hdl.handle.net/1828/14711
dc.language.isoenen_US
dc.publisherComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiologyen_US
dc.rightsAttribution-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/2.5/ca/*
dc.subjectBreast and gynecologic cancersen_US
dc.subjectMenopauseen_US
dc.subjectNutrient-sensing signaling pathwaysen_US
dc.subjectOocyte qualityen_US
dc.subjectReproductive agingen_US
dc.subjectToxicologyen_US
dc.titleC. elegans as a model organism to study female reproductive healthen_US
dc.typePostprinten_US

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