Investigating the loss of Complement Factor D on Complement Activity in the Stargardt Disease Mouse Model

dc.contributor.authorGriffith, Kaitlin
dc.date.accessioned2023-03-20T22:09:00Z
dc.date.available2023-03-20T22:09:00Z
dc.date.copyright2023en_US
dc.date.issued2023-03-20
dc.date.issued2023-03-20
dc.description.abstractStargardt disease is the most common form of macular degeneration affecting children and young adults (Fujinami et al., 2015). This condition is, in part, caused by the dysregulation of the complement system leading to inflammation in tissue that is critical for vision. Complement Factor D (Cfd) is the rate limiting enzyme in the alternative complement pathway. We hypothesize that the loss of Cfd in the Stargardt disease mouse model will rescue the phenotype and reduce the pathological inflammation. This project investigates complement activity by developing a western blot assay to measure inactive (C3) and active (C3b) forms of complement to determine whether the loss of Cfd reduces complement activity. If the loss of Cfd rescues the phenotype observed in Stargardt model mice, this would support Cfd as a target for inhibition through pharmaceutical or gene therapy.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelUndergraduateen_US
dc.description.sponsorshipJamie Cassels Undergraduate Research Awards (JCURA)en_US
dc.identifier.urihttp://hdl.handle.net/1828/14913
dc.language.isoenen_US
dc.subjectwestern bloten_US
dc.subjectStargardt diseaseen_US
dc.subjectmacular degenerationen_US
dc.subjectBiologyen_US
dc.titleInvestigating the loss of Complement Factor D on Complement Activity in the Stargardt Disease Mouse Modelen_US
dc.typePosteren_US

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