Micrometastatic node-positive breast cancer: an analysis of survival outcomes and prognostic impact of the number of positive nodes and the ratio of positive to excised nodes in comparison to node-negative and macrometastatic node-positive breast cancer
| dc.contributor.author | Li, Karen Hui | |
| dc.contributor.supervisor | Lesperance, M. L. | |
| dc.date.accessioned | 2009-04-30T17:32:11Z | |
| dc.date.available | 2009-04-30T17:32:11Z | |
| dc.date.copyright | 2009 | en |
| dc.date.issued | 2009-04-30T17:32:11Z | |
| dc.degree.department | Dept. of Mathematics and Statistics | en |
| dc.degree.level | Master of Science M.Sc. | en |
| dc.description.abstract | In this study, we examined survival for patients with micrometastases greater than 0.2mm but less than 2mm (pN1a) in comparison to node-negative (pN0) and macrometastatic node-positive (pN1b) patients. Data for patients diagnosed from 1988 to 1998 with TNM pathological T1-2 stage, pN0, and pN1a-b breast cancer with no distant metastasis was provided by Dr. P. Truong from BC Cancer Agency. Results obtained from the Kaplan-Meier estimators and the multivariable Cox Proportional Hazards Model analyses suggested that micrometastatic node-positive patients had worse survival than the node-negative patients, but better survival in comparison to the macrometastatic node-positive patients. Increasing number of positive nodes and larger values of the ratio of positive to excised nodes were significantly associated with worse survival. | en |
| dc.identifier.uri | http://hdl.handle.net/1828/1393 | |
| dc.language | English | eng |
| dc.language.iso | en | en |
| dc.rights | Available to the World Wide Web | en |
| dc.subject | Breast cancer | en |
| dc.subject | micrometastasis | en |
| dc.subject | Cox PH model | en |
| dc.subject | positive nodes | en |
| dc.subject | lymph node ratio | en |
| dc.subject.lcsh | UVic Subject Index::Sciences and Engineering::Mathematics::Mathematical statistics | en |
| dc.title | Micrometastatic node-positive breast cancer: an analysis of survival outcomes and prognostic impact of the number of positive nodes and the ratio of positive to excised nodes in comparison to node-negative and macrometastatic node-positive breast cancer | en |
| dc.type | Thesis | en |