Interhemispheric migration of resident macrophages and microglia in the stroke brain
| dc.contributor.author | Templeman, Julia | |
| dc.date.accessioned | 2026-02-04T20:11:29Z | |
| dc.date.available | 2026-02-04T20:11:29Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Confocal microscopy and immunohistochemistry were used to observe the interhemispheric migration of immune cells in the brains of mice after an induced stroke. When a sham stroke was induced in the brains of Cx3Cr1-GFP female mice there was no immune cell migration from the injected to the stroke hemisphere, but when an ischemic stroke was induced, there was significant migration towards the stroke area. Further immunohistochemistry determined that the majority of these migrating cells were resident brain macrophages, and none of them were microglia. This study also revealed a non macrophage, non microglial cell type that carried 34.91% of the microspheres towards the stroke. They are presumed to be immune cells that do not express the fractalkine receptor CX3CR1 such as neutrophils, dendritic cells, myeloid cells, or monocytes. More research with more cellular labels is needed in order to fully elucidate the phenotype of these cells. These results show that a stroke does provoke the interhemispheric migration of resident brain macrophages in the female mouse brain. | |
| dc.description.reviewstatus | Unreviewed | |
| dc.description.scholarlevel | Undergraduate | |
| dc.identifier.uri | https://hdl.handle.net/1828/23121 | |
| dc.language.iso | en | |
| dc.subject.department | Department of Biology | |
| dc.title | Interhemispheric migration of resident macrophages and microglia in the stroke brain | |
| dc.type | Honours thesis |
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