Computational models for research in medicine and desalination

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dc.contributor.authorFreiburger, Andrew
dc.contributor.supervisorBuckley, Heather L.
dc.date.accessioned2022-04-27T00:23:29Z
dc.date.copyright2022en_US
dc.date.issued2022-04-26
dc.degree.departmentDepartment of Civil Engineering
dc.degree.levelMaster of Applied Science M.A.Sc.en_US
dc.description.abstractThe development of sustainable and practical technologies is essential for the continuation of civilization. Two problems that are particularly imperative for society to resolve are 1) water insecurity and 2) antimicrobial resistance. Water insecurity may be alleviated with desalination technologies, however, desalination is prone to a membrane fouling that hinders its practicality for low-resource contexts. The two primary types of membrane fouling are scaling -- mineral precipitation and deposition upon the membrane -- and biofouling -- microbial colonization of the polymeric filtration membrane. The treatment of biofouling with antibiotics is intertwined with the antimicrobial resistance (AMR) crisis, where AMR infections are projected to exceed cancer in annual deaths by the mid-21st century. The AMR crisis may be mitigated through photodynamic inactivation (PDI), which uses reactive oxygen species (ROSs) to non-selectively oxidize and kill pathogens sufficiently fast to avoid adaptive mechanisms that result in AMR. The innumerable possible combinations of control and experimental variables in studies of membrane fouling and PDI are unlikely to be completely explored experimentally, where resource limitations restrain experimentation. This Thesis, therefore, developed models and Python application programming interfaces (APIs) that can 1) explore continuums of parameter values and 2) predict the efficacy of desalination or PDI systems. These open-source Python modules may expedite the development of practical technologies that resolve water insecurity and stymie antibiotic resistant epidemics, thereby improving the likelihood of a long-lived civilization far into the future.en_US
dc.description.embargo2023-04-05
dc.description.scholarlevelGraduateen_US
dc.identifier.urihttp://hdl.handle.net/1828/13880
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjectchemistryen_US
dc.subjectgeochemistryen_US
dc.subjectdesalinationen_US
dc.subjectwateren_US
dc.subjectbiofilmen_US
dc.subjectcellen_US
dc.subjectmodelen_US
dc.subjectbiochemistryen_US
dc.subjectbiologyen_US
dc.subjectphotochemistryen_US
dc.subjectphotodynamicen_US
dc.subjectcivilen_US
dc.subjectsoftwareen_US
dc.subjectengineeringen_US
dc.subjectmedicineen_US
dc.subjectantibioticen_US
dc.titleComputational models for research in medicine and desalinationen_US
dc.typeThesisen_US

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