Multifunctional Electrospun Scaffolds for Promoting Neuronal Differentiation of Induced Pluripotent Stem Cells

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dc.contributor.authorMohtaram, Nima Khadem
dc.contributor.authorKo, Junghyuk
dc.contributor.authorMontgomery, Amy
dc.contributor.authorCarlson, Michael
dc.contributor.authorSun, Lin
dc.contributor.authorWong, Alix
dc.contributor.authorRobinson, Meghan
dc.contributor.authorJun, Martin Byung-Guk
dc.contributor.authorWillerth, Stephanie
dc.date.accessioned2016-04-22T22:52:59Z
dc.date.available2016-04-22T22:52:59Z
dc.date.copyright2014en_US
dc.date.issued2014-11
dc.description.abstractNanofabrication techniques can produce biomaterial scaffolds that mimic the microenvironment present in healthy tissue. In this study, we used solution electrospinning to produce nanofiber-based biomaterial scaffolds that present chemical and physical cues similar to those found in the extracellular matrix of neural tissue. These electrospun biomaterial scaffolds fabricated out of poly(γ-caprolactone) (PCL) had different topographies consisting of randomly-oriented fibers and aligned fibers that contained different concentrations of retinoic acid (RA), a small molecule that regulates neural development. These scaffolds released RA in a controlled fashion for a month in the absence of cells. They also supported the differentiation of neural progenitors derived from mouse induced pluripotent stem cells (iPSCs) into neurons. Overall, this novel combination of multifunctional scaffolds and iPSC-derived neural progenitors serves as a promising strategy for neural tissue engineering applications.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationMohtaram, N.K., Ko, J., Montgomery, A., Carlson, M., Sun, L., Wong, A., … Willerth, S.M. (2014). Multifunctional electrospun scaffolds for promoting neuronal differentiation of induced pluripotent stem cells. Journal of Biomaterials and Tissue Engineering, 4(11), 906-914.en_US
dc.identifier.urihttp://dx.doi.org/10.1166/jbt.2014.1223
dc.identifier.urihttp://hdl.handle.net/1828/7176
dc.language.isoenen_US
dc.publisherJournal of Biomaterials and Tissue Engineeringen_US
dc.subjectControlled Releaseen_US
dc.subjectElectrospinningen_US
dc.subjectInduced Pluripotent Stem Cellsen_US
dc.subjectNanofibersen_US
dc.subjectNeural Tissue Engineeringen_US
dc.subjectSpinal Cord Injuryen_US
dc.titleMultifunctional Electrospun Scaffolds for Promoting Neuronal Differentiation of Induced Pluripotent Stem Cellsen_US
dc.typeArticleen_US

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