Design, synthesis and characterization of acyclic bola-amphiphiles that form ion channels

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dc.contributor.authorEggers, Paul Kahuen_US
dc.date.accessioned2024-08-13T22:12:35Z
dc.date.available2024-08-13T22:12:35Z
dc.date.copyright2001en_US
dc.date.issued2001
dc.degree.departmentDepartment of Chemistry
dc.degree.levelMaster of Science M.Sc.en
dc.description.abstractA demacrocyclization design strategy for the creation of ion channel-forming compounds was explored. Beginning with an active bis-macrocyclic bola-amphiphile, two and four tailed acyclic bola-amphiphiles were identified. These target compounds were prepared by a modular synthetic approach based on ester and amide linking reactions resulting in an increased overall yield from previous macrocyclic compounds. Transport activity was measured by pH-stat titration methods. All three compounds exhibited significantly high activity. The compound containing central esters was clearly less active than the compounds containing central amides. All compounds are apparently strongly partitioned to a vesicle bilayer membrane.
dc.format.extent124 pages
dc.identifier.urihttps://hdl.handle.net/1828/17686
dc.rightsAvailable to the World Wide Weben_US
dc.titleDesign, synthesis and characterization of acyclic bola-amphiphiles that form ion channelsen_US
dc.typeThesisen_US

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