Molecular mechanisms of reelin in the enteric nervous system and the microbiota–gut–brain axis: Implications for depression and antidepressant therapy

Simple item page
dc.contributor.authorHalvorson, Ciara S.
dc.contributor.authorSánchez-Lafuente, Carla Liria
dc.contributor.authorJohnston, Jenessa N.
dc.contributor.authorKalynchuk, Lisa E.
dc.contributor.authorCaruncho, Hector J.
dc.date.accessioned2024-10-10T17:23:13Z
dc.date.available2024-10-10T17:23:13Z
dc.date.issued2024
dc.description.abstractCurrent pharmacological treatments for depression fail to produce adequate remission in a significant proportion of patients. Increasingly, other systems, such as the microbiome–gut–brain axis, are being looked at as putative novel avenues for depression treatment. Dysbiosis and dysregulation along this axis are highly comorbid with the severity of depression symptoms. The endogenous extracellular matrix protein reelin is present in all intestinal layers as well as in myenteric and submucosal ganglia, and its receptors are also present in the gut. Reelin secretion from subepithelial myofibroblasts regulates cellular migration along the crypt–villus axis in the small intestine and colon. Reelin brain expression is downregulated in mood and psychotic disorders, and reelin injections have fast antidepressant-like effects in animal models of depression. This review seeks to discuss the roles of reelin in the gastrointestinal system and propose a putative role for reelin actions in the microbiota–gut–brain axis in the pathogenesis and treatment of depression, primarily reflecting on alterations in gut epithelial cell renewal and in the clustering of serotonin transporters.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.description.sponsorshipL.E.K and H.J.C were supported by NSERC-DG, H.J.C was supported by CRC and CIHR-PG.
dc.identifier.citationHalvorson, C. S., Sánchez-Lafuente, C. L., Johnston, J. N., Kalynchuk, L. E., & Caruncho, H. J. (2024). Molecular mechanisms of reelin in the enteric nervous system and the microbiota–gut–brain axis: Implications for depression and antidepressant therapy. International Journal of Molecular Sciences, 25(2), Article 2. https://doi.org/10.3390/ijms25020814
dc.identifier.urihttps://doi.org/10.3390/ijms25020814
dc.identifier.urihttps://hdl.handle.net/1828/20569
dc.language.isoen
dc.publisherInternational Journal of Molecular Sciences
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantidepressant
dc.subjectcrypt–villus axis migration
dc.subjectdepression
dc.subjectenteric nervous system
dc.subjectgut–brain axis
dc.subjectmicrobiota
dc.subjectreelin
dc.titleMolecular mechanisms of reelin in the enteric nervous system and the microbiota–gut–brain axis: Implications for depression and antidepressant therapy
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
halvorson_ciara_IntJMolSci_2024.pdf
Size:
675.01 KB
Format:
Adobe Portable Document Format
Download

Collections

Faculty Publications (Medical Sciences)
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.