Prenatal THC exposure has lasting detrimental effects on the rat hippocampus

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dc.contributor.authorReid, Hannah
dc.contributor.supervisorChristie, Brian R.
dc.date.accessioned2023-09-13T19:27:23Z
dc.date.available2023-09-13T19:27:23Z
dc.date.copyright2023en_US
dc.date.issued2023-09-13
dc.degree.departmentDivision of Medical Sciencesen_US
dc.degree.levelDoctor of Philosophy Ph.D.en_US
dc.description.abstractPrenatal cannabis exposure is as common as prenatal alcohol exposure, and yet it is understudied. With the recent legalization of cannabis, it is doubly important to elucidate these effects. The hippocampus is rich in cannabinoid type 1 receptors, which are targeted by the psychoactive component of cannabis. The hippocampus is central to learning and memory and is known to be affected acutely by this drug. In this dissertation, I examine how prenatal THC exposure affects different populations of hippocampal interneurons, how morphological characteristics of microglia are altered, and hippocampal synaptic plasticity is affected, and how inhibitory and excitatory markers My findings show not only that there are alterations in all these areas, but that there are regional and sex differences in many of these changes. These results suggest that there is increased GABAA recruitment via increased gephyrin cluster sizes. In absence of other receptor changes this shows that the balance of inhibition and excitation is shifted towards inhibition. Dendritic spines decreases are consistent with human clinical findings with similar psychiatric outcomes. As interneuron densities are static compared with other outcome measures, early perturbations in the endocannabinoid system likely drive the observed interneuron alterations, which then drive spine, receptor, and plasticity alterations. This work shows that there are consequences of prenatal cannabis exposure into adulthood.en_US
dc.description.scholarlevelGraduateen_US
dc.identifier.bibliographicCitationGräfe EL, Reid H, Shkolnikov I, Conway K, Kit A, Acosta C, Christie BR (2023) Women are Taking the Hit: Examining the Unique Consequences of Cannabis Use Across the Female Lifespan Frontiers in Neuroscience.en_US
dc.identifier.bibliographicCitationChristie BR, Gross A, Willoughby A, Grafe E, Brand J, Bosdachin E, Reid H, Acosta C, Eyolfson E (2023) Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury Journal of Visualized Experiments. (191), e64592, doi:10.3791/64592en_US
dc.identifier.bibliographicCitationReid H, Snowden T, Shkolnikov I, Breit K, Rodriguez C, Thomas JD, Christie BR (2021) Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus. Alcoholism: Clinical and Experimental Research 45(11):2246-2255en_US
dc.identifier.bibliographicCitationReid H*, Chen-Mack N*, Snowden TM, Christie BR (2021) Understanding Changes in Hippocampal Interneuron Subtypes in the Pathogenesis of Alzheimer's Disease: A Systematic Review. Brain Connectivity 11 (3), 159-179en_US
dc.identifier.bibliographicCitationSnowden TM, Reid H, Kennedy S, Kenny R, McQuarrie A, Stuart-Hill L, Garcia-Barrera MA, Gawryluk J, Christie BR (2020) Heading in the right direction: a critical review of studies examining the effects of heading in soccer players. Journal of Neurotrauma 38 (2), 169-188en_US
dc.identifier.bibliographicCitationSawchuck S, Reid H, Neale K, Shin J, Christie BR (2020) Effects of ethanol on synaptic plasticity and NMDA currents in the juvenile rat dentate gyrus Brain Plasticity 6 (1), 123-136en_US
dc.identifier.bibliographicCitationReid H, Lysenko-Martin M, Snowden TM, Thomas JD, Christie BR (2020) A systematic review of the effects of perinatal alcohol exposure and perinatal marijuana exposure on adult neurogenesis in the dentate gyrus. Alcoholism Clinical and Experimental Research. 44 (6), 1164-1174en_US
dc.identifier.bibliographicCitationSnowden TM, Hinde A, Reid H, Christie BR. (2020) Does mild traumatic brain injury increase the risk for dementia? A systematic review and meta-analysis. Journal of Alzheimer’s Disease 78 (2), 757-775en_US
dc.identifier.bibliographicCitationChristie BR, Trevino-Paredes J*, Pinar C*, Neale K*, Meconi A*, Reid H, Hutton C (2019) A Rapid Neurological Assessment Protocol for Repeated Mild Traumatic Brain Injury in Awake Rats. Current Protocols in Neuroscience. 89:1, e80.en_US
dc.identifier.urihttp://hdl.handle.net/1828/15376
dc.languageEnglisheng
dc.language.isoenen_US
dc.rightsAvailable to the World Wide Weben_US
dc.subjecthippocampusen_US
dc.subjectinterneuronen_US
dc.subjectTHCen_US
dc.subjectcannabisen_US
dc.titlePrenatal THC exposure has lasting detrimental effects on the rat hippocampusen_US
dc.typeThesisen_US

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