Cell Culture of Human Dermal Fibroblasts and Efficacy of Lipid Nanoparticles Used in COVID-19 Vaccines
Date
2022-09-07
Authors
Hood, McKayla
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Abstract
Over the summer, I focused on culturing human dermal fibroblasts and writing sections for a review on nanotechnology and its uses during the COVID-19 pandemic. For the dermal fibroblasts, I seeded cells into flasks and took care of them so they could grow well without contamination. Once the flasks had a high enough cell density, I extracted the cells and stored them in liquid nitrogen. I kept a few from the passage to grow more batches. For the COVID-19 review, one of the sections I researched for was on mRNA vaccines and their utilizations of lipid nanoparticles. I primarily focused on the efficacy of using lipid nanoparticles and potential toxic effects of implementing lipid nanoparticles.
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Keywords
HDF, materials, COVID-19, fibroblasts, nanotechnology, lipids, lipid nanoparticles, mRNA, vaccines, cell culture, Valerie Kuehne Undergraduate Research Awards (VKURA)