Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery

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dc.contributor.authorJanmohammadi, Mahsa
dc.contributor.authorNazemi, Zahra
dc.contributor.authorSalehi, Amin Orash Mahmoud
dc.contributor.authorSeyfoori, Amir
dc.contributor.authorJohn, Johnson V.
dc.contributor.authorNourbakhsh, Mohammad Sadegh
dc.contributor.authorAkbari, Mohsen
dc.date.accessioned2023-12-18T23:47:01Z
dc.date.available2023-12-18T23:47:01Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.description.abstractNatural bone constitutes a complex and organized structure of organic and inorganic components with limited ability to regenerate and restore injured tissues, especially in large bone defects. To improve the reconstruction of the damaged bones, tissue engineering has been introduced as a promising alternative approach to the conventional therapeutic methods including surgical interventions using allograft and autograft implants. Bioengineered composite scaffolds consisting of multifunctional biomaterials in combination with the cells and bioactive therapeutic agents have great promise for bone repair and regeneration. Cellulose and its derivatives are renewable and biodegradable natural polymers that have shown promising potential in bone tissue engineering applications. Cellulose-based scaffolds possess numerous advantages attributed to their excellent properties of non-toxicity, biocompatibility, biodegradability, availability through renewable resources, and the low cost of preparation and processing. Furthermore, cellulose and its derivatives have been extensively used for delivering growth factors and antibiotics directly to the site of the impaired bone tissue to promote tissue repair. This review focuses on the various classifications of cellulose-based composite scaffolds utilized in localized bone drug delivery systems and bone regeneration, including cellulose-organic composites, cellulose-inorganic composites, cellulose-organic/inorganic composites. We will also highlight the physicochemical, mechanical, and biological properties of the different cellulose-based scaffolds for bone tissue engineering applications.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipM.A. and A.S. acknowledge the support received from the Natural Sciences and Engineering Research Council of Canada (NSERC).en_US
dc.identifier.citationJanmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023). Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery. Bioactive Materials, 20, 137-163. https://doi.org/10.1016/j.bioactmat.2022.05.018en_US
dc.identifier.urihttps://doi.org/10.1016/j.bioactmat.2022.05.018
dc.identifier.urihttp://hdl.handle.net/1828/15726
dc.language.isoenen_US
dc.publisherBioactive Materialsen_US
dc.subjectCelluloseen_US
dc.subjectCellulose derivativesen_US
dc.subjectBone tissue engineeringen_US
dc.subjectDrug delivery systemen_US
dc.subjectLaboratory for Innovations in Micro Engineering (LiME)
dc.titleCellulose-based composite scaffolds for bone tissue engineering and localized drug deliveryen_US
dc.typeArticleen_US

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