• Investigating the Patterns of Vascular Remodelling in the Healthy Adult Mouse Cortex 

  Raudales, Alejandra (2023-02-10)

  Angiogenesis (the sprouting of new blood vessels from pre-existing ones) is a process that occurs naturally during many physiological and pathological processes. Given that the cerebral vasculature requires tight regulation ...
• Prediction Errors of Decision Demands Influence Cost-Benefit Computations in Reasoning 

  Williams, Chad (2022-09-28)

  For each decision we make, we must first determine the degree of effort that we are going to exert, and this can range from no effort to full effort. To select a reasoning strategy (e.g., withholding or exerting effort), ...
• Mechanisms and circuitry underlying direction selectivity in the mouse retina 

  Hanson, Laura (2022-04-28)

  Vision is a key sensory modality that is essential for survival. In the vertebrate visual system, light signals detected by photoreceptors are highly processed in the retina itself before being relayed to higher-order ...
• The antidepressant-like effects of intravenous reelin in the repeated-corticosterone paradigm of chronic stress 

  Allen, Josh (2022-04-28)

  Depression is an extremely common, devastating psychiatric syndrome with profound effects on the structure of neurons and the proteins that they express. However, the pathophysiology of depression remains unclear despite ...
• Sensory-evoked activity in somatosensory cortex as a model to probe cortical plasticity in a mouse model of Rett syndrome 

  Farhoomand, Farnoosh (2021-08-30)

  Rett syndrome (RTT), a severe neurodevelopmental disorder, affects females resulting from loss-of-function mutations in the X-linked transcription factor methyl-CpG-binding protein 2 (MECP2). RTT patients show severe verbal, ...
• Repeated mild traumatic brain injury is associated with acute microvascular damage in juvenile male and female rats 

  Trivino Paredes, Juan Sebastian (2021-06-25)

  Traumatic Brain Injury (TBI) is a growing global health problem. Mild forms of TBI (mTBI) such as concussions, represent the most common manifestation of this type of injury with children and youth (< 20 years old) among ...
• Investigating the deleterious effects of type 1 diabetes mellitus on microvascular repair in the mouse cortex 

  Mehina, Eslam (2021-05-25)

  Microglia and brain-resident macrophages are the sentinel immune cells of the central nervous system (CNS), and are ideally situated to respond to any damage to the brain parenchyma or vasculature. Circulating leukocytes ...
• A novel preclinical pediatric concussion model causes neurobehavioural impairment and diffuse neurodegeneration 

  Meconi, Alicia Louise (2021-05-03)

  Concussions are the injury and symptoms that can result from transmission of a biomechanical force to the brain. They represent a significant global health burden, and are the subject of a growing body of medical research. ...
• Sex differences in hippocampal cell proliferation and inflammation following repeated mild traumatic brain injury in adolescent rats 

  Neale, Katie J. (2020-08-05)

  Traumatic brain injury (TBI) is becoming increasingly recognized as a global health issue. Each year over 160,000 Canadians experience some form of TBI, which can be caused by sport-related injuries, motor vehicle accidents, ...
• Pannexin 1 regulates dendritic spines in developing cortical neurons 

  Sanchez-Arias, Juan C. (2020-05-04)

  Sensory, cognitive, and emotional processing are rooted in the cerebral cortex. The cerebral cortex is comprised of six layers defined by the neurons within them that have distinctive connection, both within cortex itself ...
• Longitudinal calcium imaging of VIP interneuron circuits reveals shifting response fidelity dynamics in the stroke damaged brain 

  Motaharinia, Mohammad (2020-01-29)

  Although inhibitory cortical interneurons play a critical role in regulating brain excitability and function, the effects of stroke on these neurons is poorly understood. In particular, interneurons expressing vasoactive ...
• Determinants of brain region-specific age-related declines in microvascular density in the mouse brain 

  Schager, Benjamin (2020-01-27)

  It is emerging that the brain’s vasculature consists of a highly spatially heterogeneous network; however, information on how various vascular characteristics differ between brain regions is still lacking. Furthermore, ...
• Effects of mild traumatic brain injury on hippocampal synaptic plasticity and behaviour in juvenile rats 

  Pinar Cabeza de Vaca, Cristina (2019-12-11)

  Traumatic Brain Injury (TBI) is a global health problem and concussion, or mild TBI (mTBI), accounts for up to 75% of all brain injuries occurring annually in the US. There is also growing awareness that repeated mild ...
• Regulation of Cav2.1 by Ankyrin B and its variants 

  Choi, Catherine S.W. (2019-08-19)

  Ankyrin B (AnkB) is a scaffolding protein, acting as a bridge between ion channels and cytoskeleton networks. AnkB variants are associated with cognitive disorders including autism spectrum disorder and epilepsy. In the ...
• Exploiting evolutionarily conserved pathways to promote plasticity of human spinal circuits 

  Pearcey, Gregory E. P. (2019-06-18)

  Humans evolved from species that walked on all four limbs, which means that experiments in quadrupeds can guide and support experiments in humans. This is particularly helpful for neural rehabilitation because the central ...
• Ethanol modulation of NMDA receptors and NMDAr-dependent long-term depression in the developing juvenile dentate gyrus 

  Sawchuk, Scott D. (2019-05-01)

  Long-term depression (LTD) induced by low frequency stimulation (LFS; 900x1Hz) at medial perforant path (MPP) synapses in the rat dentate gyrus (DG) has been described as both developmentally regulated and N-methyl D-aspartate ...
• Role of a novel C-terminal motif in Pannexin 1 trafficking and oligomerization 

  Epp, Anna (2019-04-24)

  Pannexin 1 (Panx1) is a metabolite channel enriched in the brain and known to localize to the cell surface, where it is involved in a variety of neuronal processes including cell proliferation and differentiation. The ...
• Rhythmic arm cycling training improves walking and interlimb integrity in chronic stroke 

  Kaupp, Chelsea (2018-12-24)

  Training locomotor pattern generating networks (CPGs) with body weight supported treadmill training or through arm and leg cycling improves walking in chronic stroke. These outcomes are presumed to result from enhanced ...
• Not all is lost; prenatal ethanol exposure impairs bidirectional synaptic plasticity in the juvenile dentate gyrus 

  Fontaine, Christine Jessie (2018-12-20)

  Fetal alcohol spectrum disorders (FASDs) are among the leading preventable disorders in North America and are caused by prenatal ethanol exposure (PNEE). Ethanol is a teratogen, and prenatal exposure leads to structural ...
• Do sub-concussive impacts from soccer heading in practice cause changes in brain structure and function? 

  Kenny, Rebecca (2018-09-11)

  Background: Heading is an important part of soccer, yet recent research has indicated that cumulative effects of repetitive heading may cause sub-concussive injury (Koerte et al., 2015). Objective: The current study aimed ...

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