• A scoping review of rodent studies investigating the epigenetic mechanisms in the brain underlying the effects of diet on depressive-like behaviour 

  Sánchez-Lafuente, Carla L.; Reive, Brady S.; Kalynchuk, Lisa E.; Caruncho, Hector J. (Biomedicines, 2022)

  A healthy diet has been highly associated with a decreased risk for mental health problems such as major depression. Evidence from human studies shows that diet can influence mood but there is a poor understanding of the ...
• Editorial: Cannabinoids in neuroinflammation, neurodegeneration and pain: Focus on non-neuronal cells 

  Vecchiarelli, Haley A.; Joers, Valerie; Tansey, Malú Gámez; Starowicz, Katarzyna (Frontiers in Neuroscience, 2022)
• An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system 

  Komal, Pragya; Manjari, S. K. V.; Nashmi, Raad (IBRO Neuroscience Reports, 2022)

  In recent years scientific research has established that the nervous and immune systems have shared molecular signaling components. Proteins native to immune cells, which are also found in the brain, have neuronal functions ...
• Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer's disease pathology and in human post-mortem brain samples 

  St-Pierre, Marie-Kim; Carrier, Micaël; González Ibáñez, Fernando; Šimončičová, Eva; Wallman, Marie-Josée; Vallières, Luc; Parent, Martin; Tremblay, Marie-Ève (Journal of Neuroinflammation, 2022)

  A diverse heterogeneity of microglial cells was previously described in Alzheimer’s disease (AD) pathology, including dark microglia, a state characterized by ultrastructural markers of cellular stress. To provide novel ...
• A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells 

  Lounas, Amel; Lebrun, Ariane; Laflamme, Isabelle; Vernoux, Nathalie; Savage, Julie; Tremblay, Marie-Ève; Germain, Marc; Richard, François J. (Scientific Reports, 2022)

  In the ovarian follicle, a bilateral cell-to-cell communication exists between the female germ cell and the cumulus cells which surround the oocyte. This communication allows the transit of small size molecules known to ...
• Crisis brings innovative strategies: Collaborative empathic teleintervention for children with disabilities during the COVID-19 lockdown 

  Schiariti, Verónica; McWilliam, Robin A. (International Journal of Environmental Research and Public Health, 2021)

  Background: While coronavirus disease 2019 (COVID-19) continues to spread across the globe, public health strategies—including the social distancing measures that many countries have implemented— have caused disruptions ...
• The endocannabinoid system in glial cells and their profitable interactions to treat epilepsy: Evidence from animal models 

  Egaña-Huguet, Jon; Soria-Gómez, Edgar; Grandes, Pedro (International Journal of Molecular Sciences, 2021)

  Epilepsy is one of the most common neurological conditions. Yearly, five million people are diagnosed with epileptic-related disorders. The neuroprotective and therapeutic effect of (endo)cannabinoid compounds has been ...
• Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease 

  de Paula Nascimento-Castro, Cristine; Winkelmann-Duarte, Elisa C.; Mancini, Gianni; Welter, Priscilla Gomes; Plácido, Evelini; Farina, Marcelo; Gil-Mohapel, Joana; Rodrigues, Ana Lúcia S.; de Bem, Andreza Fabro; Brocardo, Patricia S. (Biomedicines, 2022)

  Huntington’s disease (HD) is a genetic neurodegenerative disease characterized by motor, psychiatric, and cognitive symptoms. Emerging evidence suggests that emotional and cognitive deficits seen in HD may be related to ...
• Molecular basis underlying the therapeutic potential of vitamin D for the treatment of depression and anxiety 

  Kouba, Bruna R.; Camargo, Anderson; Gil-Mohapel, Joana; Rodrigues, Ana Lúcia S. (International Journal of Molecular Sciences, 2022)

  Major depressive disorder and anxiety disorders are common and disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms of depression and anxiety frequently overlap in ...
• Alcohol use disorder: Neurobiology and therapeutics 

  Yang, Waisley; Singla, Rohit; Maheshwari, Oshin; Fontaine, Christine J.; Gil-Mohapel, Joana (Biomedicines, 2022)

  Alcohol use disorder (AUD) encompasses the dysregulation of multiple brain circuits involved in executive function leading to excessive consumption of alcohol, despite negative health and social consequences and feelings ...
• Postnatal choline supplementation rescues deficits in synaptic plasticity following prenatal ethanol exposure 

  Grafe, Erin L.; Wade, Mira M. M.; Hodson, Claire E.; Thomas, Jennifer D.; Christie, Brian R. (Nutrients, 2022)

  Prenatal ethanol exposure (PNEE) is a leading cause of neurodevelopmental impairments, yet treatments for individuals with PNEE are limited. Importantly, postnatal supplementation with the essential nutrient choline can ...
• Prevention of L-Dopa-induced dyskinesias by MPEP blockade of metabotropic glutamate receptor 5 is associated with reduced inflammation in the brain of Parkinsonian monkeys 

  Morissette, Marc; Bourque, Mélanie; Tremblay, Marie-Ève; Di Paolo, Thérèse (Cells, 2022)

  Proinflammatory markers were found in brains of Parkinson’s disease (PD) patients. After years of L-Dopa symptomatic treatment, most PD patients develop dyskinesias. The relationship between inflammation and L-Dopa-induced ...
• The role of MeCP2 in regulating synaptic plasticity in the context of stress and depression 

  Sánchez-Lafuente, Carla L.; Kalynchuk, Lisa E.; Caruncho, Hector J.; Ausió, Juan (Cells, 2022)

  Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant in the brain. It binds to methylated genomic DNA to regulate a range of physiological functions implicated in neuronal development ...
• The Effects of Self-Relevance on Neural Learning Signals Indexing Attention, Perception, and Learning 

  Rocha Hammerstrom, Mathew (2022-09-28)

  Humans tend to preferentially process information relevant to themselves. For instance, in experiments where participants learn to manipulate stimuli referenced to themselves or someone else, participants exhibit larger ...
• A Comparison of White Matter Microstructure and its Relationship with Cognition in Younger and Older Adults 

  Sheriff, Abu-Bakar (2022-09-13)

  Background: Given the growing aging population, it is crucial to better understand the neurobiological underpinnings of healthy aging and how changes in structure relate to changes in function. The current study derived ...
• Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle 

  Corsi, Giorgio; Picard, Katherine; di Castro, Maria Amalia; Garofalo, Stefano; Tucci, Federico; Chece, Giuseppina; del Percio, Claudio; Golia, Maria Teresa; Raspa, Marcello; Scavizzi, Ferdinando; Decoeur, Fanny; Lauro, Clotilde; Rigamonti, Mara; Iannello, Fabio; Ragozzino, Davide Antonio; Russo, Eleonora; Bernardini, Giovanni; Nadjar, Agnès; Tremblay, Marie Eve; Babiloni, Claudio (Glia, 2022)

  Microglia, the brain's resident macrophages, actively contribute to the homeostasis of cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and plasticity. While several studies demonstrated ...
• CCCDTD5 recommendations on the deprescribing of cognitive enhancers in dementia 

  Henri-Bhargava, Alexandre; Herrmann, Nathan; Ismail, Zahinoor; Collins, Rhonda; Desmarais, Philippe; Goodarzi, Zahra; Iaboni, Andrea; Kirkham, Julia; Massoud, Fadi; Moser, Andrea; Silvius, James; Watt, Jennifer; Seitz, Dallas (Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022-01-31)

  Introduction Cognitive enhancers (ie, cholinesterase inhibitors and memantine) can provide symptomatic benefit for some individuals with dementia; however, there are circumstances in which the risks of continuing treatment ...
• Gut microbes shape microglia and cognitive function during malnutrition 

  Han, Jun; Bauer, Kylynda C.; York, Elisa M.; Cirstea, Mihai S.; Radisavljevic, Nina; Petersen, Charisse; Huus, Kelsey E.; Brown, Eric M.; Bozorgmehr, Tahereh; Berdun, Rebeca; Bernier, Louis-Philippe; Lee, Amy H. Y.; Woodward, Sarah E.; Krekhno, Zakhar; Hancock, Robert E. W.; Ayala, Victoria; MacVicar, Brian A.; Finlay, Barton Brett (GLIA, 2022-01-12)

  Fecal-oral contamination promotes malnutrition pathology. Lasting consequences of early life malnutrition include cognitive impairment, but the underlying pathology and influence of gut microbes remain largely unknown. ...
• Affinity Purification Coupled to Stable Isotope Dilution LC-MS/MS Analysis to Discover IgG4 Glycosylation Profiles for Autoimmune Pancreatitis 

  Chen, Michael X.; Su, Ho-Hsuan; Shiao, Ching-Ya; Chang, Yu-Ting; Chang, Ming-Chu; Kao, Chih-Chin; Wang, San-Yuan; Shih, His-Chang; Tsai, I-Lin (International Journal of Molecular Sciences, 2021)

  Type 1 autoimmune pancreatitis (AIP) is categorized as an IgG4-related disease (IgG4-RD), where a high concentration of plasma IgG4 is one of the common biomarkers among patients. IgG Fc-glycosylation has been reported ...
• New Avenues for the Treatment of Huntington's Disease 

  Kim, Amy; Lalonde, Kathryn; Truesdell, Aaron; Gomes Welter, Priscilla; Brocardo, Patricia S.; Rosenstock, Tatiana R.; Gil-Mohapel, Joana (International Journal of Molecular Sciences, 2021)

  Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum and cortex. The first symptoms usually ...

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