• Understanding the molecular basis of regulation of class I PI3Ks by activation signals, oncogenic mutations, and post-translational modifications 

  Ranga Prasad, Harish (2022-12-22)

  Class I Phosphoinostide-3 Kinases (PI3K) generate Phosphatidylinositol-3, 4, 5 Trisphosphate (PIP3), which regulates important cellular tasks such as proliferation, cell growth, survival and metabolism through membrane ...
• The influence of thyroid hormone and temperature on the transcriptomic response of Rana [Lithobates] catesbeiana tadpole cultured back skin 

  Evans, Ellis (2022-09-02)

  Thyroid hormones (THs) are essential signaling molecules for the postembryonic development of all vertebrates. THs are capable of initiating a diverse set of developmental programs across multiple tissues. The role of TH ...
• The Development and Application of Mass Spectrometry-based Structural Proteomic Approaches to Study Protein Structure and Interactions 

  Makepeace, Karl A.T. (2022-08-26)

  Proteins and their intricate network of interactions are fundamental to many molecular processes that govern life. Mass spectrometry-based structural proteomics represents a powerful set of techniques for characterizing ...
• Characterization of ReNCell for studying chromatin associated proteins MeCP2 and histone H1 

  Kim, Bo Hyun "Cindy" (2022-08-05)

  Methyl-CpG binding protein 2 (MeCP2) and histone H1 are important chromatin associated proteins. Both exhibit their own extent of complexity as MeCP2 is an intrinsically disordered protein (IDP) that interacts with many ...
• Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity 

  Perez, M.M. (2022-04-27)

  The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism ...
• Immune regulatory metabolites in the tumor microenvironment suppress T cell function in ovarian cancer 

  Kilgour, Marisa (2022-04-26)

  Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients ...
• Advancing understanding of secondary cell wall polymer binding and synthesis in S-layers of Gram-Positive bacteria 

  Legg, Max (2022-04-21)

  Self-assembling protein surface layers (S-layers) are ubiquitous prokaryotic cell-surface structures involved in structural maintenance, nutrient diffusion, host adhesion, virulence, and many additional processes, which ...
• Deciphering the immunosuppressive landscape of high-grade serous ovarian cancer 

  Smazynski, Julian (2022-01-19)

  High-grade serous ovarian cancer (HGSC) remains the most common and lethal subtype of ovarian cancer with a 5-year survival rate of ~30%, highlighting an urgent need for new treatments. Cancer immunotherapy has emerged as ...
• The effects of a helminth-altered gut metabolome and deworming on host immunity 

  Brosschot, Tara Pauline (2021-12-22)

  Helminths are parasitic worms that can establish long-lived infections by modulating host immune responses. Helminth infection has been associated with a reduced prevalence of allergic disease in human populations, and ...
• Understanding the molecular basis of Rab-GEF activity and specificity of the mammalian TRAPP complexes 

  Harris, Noah James (2021-09-23)

  Rab GTPases are among the most important families of proteins involved in regulating the trafficking and delivery of cellular cargo to their proper locations. The multi-subunit Transport Protein Particle complexes, TRAPPII ...
• The chilling tail of temperature’s influence on thyroid hormone signalling in the post-embryonic developmental response of Rana catesbeiana cultured tail fin 

  Koide, Emily (2021-09-14)

  Thyroid hormone (TH) is a critical signalling molecule for all vertebrate organisms, playing an especially crucial role in postembryonic development. Given its importance, many studies have focused on further elucidating ...
• Development of automated iMALDI assays for the robust quantitation of cell signalling proteins in the PI3K pathway to improve guided cancer treatment 

  Frohlich, Bjorn Christian (2021-08-30)

  The PI3-kinase/AKT/mTOR pathway plays a central role in cancer signaling. While p110α is the catalytic α-subunit of PI3-kinase and a major drug target, PTEN is the main negative regulator of the PI3-kinase/AKT/mTOR pathway. ...
• Dissecting the role of bifunctional histone chaperone Fpr4 in transcription and recombination 

  Kirlikaya, Baran (2021-08-25)

  Eukaryotic DNA is wrapped around nucleosomes and assembled into chromatin, which is the substrate for DNA-centric processes including transcription and recombination. Histone chaperones are central players in these processes ...
• Seeing through the clip of a fin: comparing the salmonid liver and caudal fin transcriptome in demonstrating oil spill response 

  Imbery, Jacob (2021-08-25)

  Effective tracking and management of an oil spill are crucial to mitigating deleterious effects on fish. Currently, the area covered by an oil spill is tracked primarily through satellite and aerial imaging of the top ...
• Molecular basis for the regulation of phosphoinositide 3-kinase γ (PI3Kγ) 

  Rathinaswamy, Manoj Kumar (2021-07-22)

  Cells transduce signals from the external environment to the inside through phosphatidylinositol-3,4,5-phosphate (PIP3), a major signaling lipid on the plasma membrane. PIP3 is generated by the action of a family of lipid ...
• Carbohydrate processing: an indispensable platform of pneumococcal virulence 

  Meier, Edward Peter William (2021-04-30)

  Carbohydrate processing is fundamental for Streptococcus pneumoniae (pneumococcus) colonization, and it is also a major platform of its virulence. Many of the organism’s key carbohydrate processing enzymes target the glycans ...
• Interactions of Treponema pallidum with human platelets 

  Church, Brigette Monica (2021-01-06)

  Treponema pallidum ssp. pallidum is the causative agent of syphilis, a multi-stage bacterial infection, transmitted sexually or from mother-to-child, with an unparalleled range of symptoms arising from the ability of ...
• Understanding the mechanism of 177Lu- PSMA617 radioligand therapy and evaluating its potential role in the treatment of metastatic castrate resistant prostate cancer (mCRPC) 

  Joshi, Jay (2020-12-21)

  Prostate cancer is the most common cancer in men and the third leading cause of cancer-related deaths in Canadian men. Despite hormone and radiation therapies, most patients progress to late-stage metastatic castrate-resistant ...
• Origins, distribution, and ecological significance of marine microbial copper ligands 

  Nixon, Richard L. (2020-08-31)

  Copper (Cu) is required by marine microbes for essential biological processes, including photosynthesis and nitrogen fixation, but can be toxic above a certain threshold. Copper bioavailability in seawater is regulated by ...
• Characterizing the unique myosin motors driving motility and active host cell invasion by apicomplexan parasites 

  Powell, Cameron (2020-05-04)

  Phylum Apicomplexa comprises several thousand parasitic protozoans that cause significant disease in humans and animals worldwide. Of particular relevance to human health are Plasmodium spp., the causative agents of malaria; ...

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