CB1/TRPV1 antagonism ameliorates lateral perforant pathway STP/LTP deficits in a rmTBI young adolescent rat model
Date
2025
Authors
Zejnulahovic, Emir
Journal Title
Journal ISSN
Volume Title
Publisher
University Of Victoria
Abstract
There is well-established literature backing deficits in long-term potentiation (LTP), the neurological basis of learning in repetitive mild-traumatic brain injury (rmTBI) victims. Of interest are the deficits seen in the medial perforant pathway (MPP), whos neuronal input is essential for the maturation of new neurons in the dentate gyrus (DG), the site of adult neurogenesis (creation of new neurons throughout life). Young adolescents are the highest risk group for rmTBI, and are also at crucial point of neuronal development. Coupling this with the known deficits in LTP present in these groups, we are investigating the potential of a pharmacological approach to the endocannabinoid system (a regulatory neurotransmitter system) to see if an "rescue" effect is possible in these cases. With the use of AM251 (Cannabinoid 1 receptor inverse agonist) and AMG9810 (TRPV1 antagonist), we hypothesize that with the use of these drugs to alter the effects of the endocannabinoid system, we can ameliorate these LTP deficits seen in rmTBI victims in an experimental model.
Description
Keywords
rmTBI, endocannabinoids, AM251, AMG9810, lateral impact model, LTP, STP, electrophysiology