CB1/TRPV1 antagonism ameliorates lateral perforant pathway STP/LTP deficits in a rmTBI young adolescent rat model

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dc.contributor.authorZejnulahovic, Emir
dc.date.accessioned2025-04-25T15:12:19Z
dc.date.available2025-04-25T15:12:19Z
dc.date.issued2025
dc.description.abstractThere is well-established literature backing deficits in long-term potentiation (LTP), the neurological basis of learning in repetitive mild-traumatic brain injury (rmTBI) victims. Of interest are the deficits seen in the medial perforant pathway (MPP), whos neuronal input is essential for the maturation of new neurons in the dentate gyrus (DG), the site of adult neurogenesis (creation of new neurons throughout life). Young adolescents are the highest risk group for rmTBI, and are also at crucial point of neuronal development. Coupling this with the known deficits in LTP present in these groups, we are investigating the potential of a pharmacological approach to the endocannabinoid system (a regulatory neurotransmitter system) to see if an "rescue" effect is possible in these cases. With the use of AM251 (Cannabinoid 1 receptor inverse agonist) and AMG9810 (TRPV1 antagonist), we hypothesize that with the use of these drugs to alter the effects of the endocannabinoid system, we can ameliorate these LTP deficits seen in rmTBI victims in an experimental model.
dc.description.reviewstatusReviewed
dc.description.scholarlevelUndergraduate
dc.description.sponsorshipJamie Cassels Undergraduate Research Awards (JCURA)
dc.identifier.urihttps://hdl.handle.net/1828/22014
dc.language.isoen
dc.publisherUniversity Of Victoria
dc.subjectrmTBI
dc.subjectendocannabinoids
dc.subjectAM251
dc.subjectAMG9810
dc.subjectlateral impact model
dc.subjectLTP
dc.subjectSTP
dc.subjectelectrophysiology
dc.titleCB1/TRPV1 antagonism ameliorates lateral perforant pathway STP/LTP deficits in a rmTBI young adolescent rat model
dc.typePoster

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