Extrusion and Microfluidic-Based Bioprinting to Fabricate Biomimetic Tissues and Organs

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dc.contributor.authorDavoodi, Elham
dc.contributor.authorSarikhani, Einollah
dc.contributor.authorMontazerian, Hossein
dc.contributor.authorAhadian, Samad
dc.contributor.authorCostantini, Marco
dc.contributor.authorSwieszkowski, Wojciech
dc.contributor.authorWillerth, Stephanie Michelle
dc.contributor.authorWalus, Konrad
dc.contributor.authorMofidfar, Mohammad
dc.contributor.authorToyserkani, Ehsan
dc.contributor.authorKhademhosseini, Ali
dc.contributor.authorAshammakhi, Nureddin
dc.date.accessioned2020-08-22T00:19:30Z
dc.date.available2020-08-22T00:19:30Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractNext generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost‐effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical‐grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis article is part of the Advanced Materials Technologies Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of technology‐related materials science. The authors acknowledge funding from the National Institutes of Health (EB021857‐01A1, AR073135), Department of Defense: BiofabUSA Quick Start Project, the Natural Sciences and Engineering Research Council of Canada (NSERC: 50503‐10243), and the Federal Economic Development Agency for Southern Ontario (FedDev Ontario: 809104). This study was supported by the National Science Centre – Poland (NCN) within the POLONEZ 3 fellowship number 2016/23/P/NZ1/03604 which has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No. 665778 and the National Centre for Research and Development (STRATEGMED3/305813/2/NCBR/2017‐BIONIC). This work was also financially supported by the Natural Science and Engineering Research Council of Canada, the Canada Research Chairs program, the Michael Smith Foundation for Health Research, and the Pacific Parkinson's Research Institute.en_US
dc.identifier.citationDavoodi, E., Sarikhani, E., Montazerian, H., Ahadian, S., Costantini, M., Swieszkowski, W., Willerth, S. M., … & Ashammakhi, N. (2020). Extrusion and Microfluidic-Based Bioprinting to Fabricate Biomimetic Tissues and Organs. Advanced Materials Technologies, 5(8), 1-30. https://doi.org/10.1002/admt.201901044.en_US
dc.identifier.urihttps://doi.org/10.1002/admt.201901044
dc.identifier.urihttp://hdl.handle.net/1828/12019
dc.language.isoenen_US
dc.publisherAdvanced Materials Technologiesen_US
dc.subjectbioinks
dc.subjectbiomimetic materials
dc.subjectbioprinting
dc.subjectmicrofluidics
dc.subjecttissue engineering
dc.subject.departmentDepartment of Mechanical Engineering
dc.subject.departmentDepartment of Electrical and Computer Engineering
dc.titleExtrusion and Microfluidic-Based Bioprinting to Fabricate Biomimetic Tissues and Organsen_US
dc.typeArticleen_US

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