Synaptic loss in Alzheimer's disease: Mechanistic insights provided by two-photon imaging of transgenic mouse models
Date
2020
Authors
Subramanian, Jaichandar
Savage, Julie C.
Tremblay, Marie-Ève
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers in Cellular Neuroscience
Abstract
Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review, we summarize how multiphoton imaging has improved our understanding of synapse loss mechanisms associated with excessive amyloid in the living animal brain. We also discuss evidence obtained from these imaging studies for the role of cell-intrinsic calcium dyshomeostasis and cell-extrinsic activities of microglia, which are the immune cells of the brain, in mediating synapse loss.
Description
Keywords
dendritic spines, microglia, two-photon, in vivo imaging, amyloid mouse models
Citation
Subramanian, J., Savage, J. C., & Tremblay, M-È. (2020). Synaptic loss in Alzheimer's disease: mechanistic insights provided by two-photon in vivo imaging of transgenic mouse models. Frontiers in Cellular Neuroscience, 14, 592607. https://doi.org/10.3389/fncel.2020.592607