Synaptic loss in Alzheimer's disease: Mechanistic insights provided by two-photon imaging of transgenic mouse models
| dc.contributor.author | Subramanian, Jaichandar | |
| dc.contributor.author | Savage, Julie C. | |
| dc.contributor.author | Tremblay, Marie-Ève | |
| dc.date.accessioned | 2024-03-20T22:52:31Z | |
| dc.date.available | 2024-03-20T22:52:31Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this review, we summarize how multiphoton imaging has improved our understanding of synapse loss mechanisms associated with excessive amyloid in the living animal brain. We also discuss evidence obtained from these imaging studies for the role of cell-intrinsic calcium dyshomeostasis and cell-extrinsic activities of microglia, which are the immune cells of the brain, in mediating synapse loss. | |
| dc.description.reviewstatus | Reviewed | |
| dc.description.scholarlevel | Faculty | |
| dc.description.sponsorship | This work was supported by a grant from the National Institutes of Health (Grant No. R01AG064067) to JS and a Canadian Institutes of Health Research–Foundation (Grant No. 353750) to M-ÈT. M-ÈT holds a Canada Research Chair (Tier 2) in Neurobiology of Aging and Cognition. | |
| dc.identifier.citation | Subramanian, J., Savage, J. C., & Tremblay, M-È. (2020). Synaptic loss in Alzheimer's disease: mechanistic insights provided by two-photon in vivo imaging of transgenic mouse models. Frontiers in Cellular Neuroscience, 14, 592607. https://doi.org/10.3389/fncel.2020.592607 | |
| dc.identifier.uri | https://doi.org/10.3389/fncel.2020.592607 | |
| dc.identifier.uri | https://hdl.handle.net/1828/16244 | |
| dc.language.iso | en | |
| dc.publisher | Frontiers in Cellular Neuroscience | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | dendritic spines | |
| dc.subject | microglia | |
| dc.subject | two-photon | |
| dc.subject | in vivo imaging | |
| dc.subject | amyloid mouse models | |
| dc.title | Synaptic loss in Alzheimer's disease: Mechanistic insights provided by two-photon imaging of transgenic mouse models | |
| dc.type | Article |