Photochemical behavior of biosupramolecular assemblies of photosensitizers, cucurbit[n]urils and albumins

Simple item page
dc.contributor.authorCaceres, Javiera
dc.contributor.authorRobinson-Duggon, Jose
dc.contributor.authorTapia, Anita
dc.contributor.authorPaiva, Constanza
dc.contributor.authorGomez, Matias
dc.contributor.authorBohne, Cornelia
dc.contributor.authorFuentealba, Denis
dc.date.accessioned2020-08-22T00:16:26Z
dc.date.available2020-08-22T00:16:26Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractBiosupramolecular assemblies combining cucurbit[n]urils (CB[n]s) and proteins for the targeted delivery of drugs have the potential to improve the photoactivity of photosensitizers used in the photodynamic therapy of cancer. Understanding the complexity of these systems and how it affects the properties of photosensitizers is the focus of this work. We used acridine orange (AO+) as a model photosensitizer and compared it with methylene blue (MB+) and a cationic porphyrin (TMPyP4+). Encapsulation of the photosensitizers into CB[n]s (n = 7, 8) modified their photoactivity. In particular, for AO+, the photo-oxidation of HSA was enhanced in the presence of CB[7]; meanwhile it was decreased when included into CB[8]. Accordingly, peroxide generation and protein fragmentation were also increased when AO+ was encapsulated into CB[7]. The triplet excited state lifetimes of all the photosensitizers were lengthened by their encapsulation into CB[n]s, while the singlet oxygen quantum yield was enhanced only for AO+ and TMPyP4+, but it decreased for MB+. The results obtained in this work prompt the necessity of further investigating these kinds of hybrid assemblies as drug delivery systems because of their possible applications in biomedicine.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by CONICYT-FONDECYT (Grant 11121223) and at UVic by NSERC (RGPIN-121389-2012).en_US
dc.identifier.citationCaceres, J., Robinson-Duggon, J., Tapia, A., Paiva, C., Gomez, M., Bohne, C., & Fuentealba, D. (2016). Photochemical behavior of biosupramolecular assemblies of photosensitizers, cucurbit[n]urils and albumins. Physical Chemistry Chemical Physics, 19, 2574-2582. https://doi.org/10.1039/C6CP07749H.en_US
dc.identifier.urihttps://doi.org/10.1039/C6CP07749H
dc.identifier.urihttp://hdl.handle.net/1828/12017
dc.language.isoenen_US
dc.publisherPhysical Chemistry Chemical Physicsen_US
dc.subject.departmentDepartment of Chemistry
dc.titlePhotochemical behavior of biosupramolecular assemblies of photosensitizers, cucurbit[n]urils and albuminsen_US
dc.typePostprinten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Caceres_Javiera_PhysChemChemPhys_2016.pdf
Size:
1.25 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.