The role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UK

Simple item page
dc.contributor.authorCadar, Dorina
dc.contributor.authorStephan, Blossom C. M.
dc.contributor.authorJagger, Carol
dc.contributor.authorJohansson, Boo
dc.contributor.authorHofer, Scott M.
dc.contributor.authorPiccinin, Andrea M.
dc.contributor.authorMuniz-Terrera, Graciela
dc.date.accessioned2020-11-13T19:56:35Z
dc.date.available2020-11-13T19:56:35Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.description.abstractObjective Cognitive performance shows a marked deterioration in close proximity to death, as postulated by the terminal decline hypothesis. The effect of education on the rate of terminal decline in the oldest people (i.e. persons 85+ years) has been controversial and not entirely understood. In the current study, we investigated the rate of decline prior to death with a special focus on the role of education and socioeconomic position, in two European longitudinal studies of ageing: the Origins of Variance in the Old‐Old: Octogenarian Twins (OCTO‐Twin) and the Newcastle 85+ study. Methods A process‐based approach was used in which individuals' cognitive scores were aligned according to distance to death. In a coordinated analysis, multilevel models were employed to examine associations between different markers of cognitive reserve (education and socioeconomic position) and terminal decline using the mini‐mental state examination (MMSE), controlling for age at baseline, sex, dementia incidence and time to death from the study entry to the time of death within each cohort. Results The current findings suggest that education was positively associated with higher MMSE scores prior to death in the OCTO‐Twin, but not in the Newcastle 85+ study, independent of socioeconomic position and other factors such as baseline age, sex and time to death from the study entry. However, education was not associated with the rate of terminal decline in both of these studies. Conclusions Our results offer only partial support to the cognitive reserve hypothesis and cognitive performance prior to death. © 2015 The Authors International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipDr Dorina Cadar is funded by the Alzheimer's Society [grant number 144] and by the Medical Research Council [unit programme number MC_UU_12019/1]. Professor Boo Johansson is funded by the Swedish Research Council for Health, Working Life and Welfare. Professor Andrea Piccinin, Professor Scott Hofer and Dr Graciela Muniz are funded by the US National Institutes of Health/National Institute of Aging [P01AG043362]. Professor Carol Jagger is funded by the AXA Research Fund.en_US
dc.identifier.citationCadar, D., Stephan, B. C. M., Jagger, C., Johansson, B., Hofer, S. M., Piccinin, A. M., & Muniz- Terrera, G. (2015). The role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UK. International Journal of Geriatric Psychiatry, 31(6), 601-610. https://doi.org/10.1002/gps.4366.en_US
dc.identifier.urihttps://doi.org/10.1002/gps.4366
dc.identifier.urihttp://hdl.handle.net/1828/12350
dc.language.isoenen_US
dc.publisherInternational Journal of Geriatric Psychiatryen_US
dc.subjectcognition
dc.subjectdeath
dc.subjectdementia
dc.subjectMMSE
dc.subjecteducation
dc.subjectterminal decline
dc.subjectcognitive reserve
dc.subjectlongitudinal study
dc.subjectmixed multilevel
dc.subject.departmentDepartment of Psychology
dc.titleThe role of cognitive reserve on terminal decline: a cross-cohort analysis from two European studies: OCTO-Twin, Sweden, and Newcastle 85+, UKen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cadar_Dorina_IntJGeriatrPsychiatry_2015.pdf
Size:
439.15 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.