Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study

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dc.contributor.authorPenn, Andrew M.
dc.contributor.authorBibok, Maximilian B.
dc.contributor.authorSaly, Viera K.
dc.contributor.authorCoutts, Shelagh B.
dc.contributor.authorLesperance, Mary L.
dc.contributor.authorBalshaw, Robert F.
dc.contributor.authorVotova, Kristine
dc.contributor.authorCroteau, Nicole S.
dc.contributor.authorTrivedi, Anurag
dc.contributor.authorJackson, Angela M.
dc.contributor.authorHegedus, Janka
dc.contributor.authorKlourfeld, Evgenia
dc.contributor.authorYu, Amy Y. X.
dc.contributor.authorZerna, Charlotte
dc.contributor.authorBorchers, Christoph H.
dc.date.accessioned2021-01-18T23:40:12Z
dc.date.available2021-01-18T23:40:12Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.description.abstractObjective: To derive a plasma biomarker protein panel from a list of 141 candidate proteins which can differentiate transient ischaemic attack (TIA)/minor stroke from non-cerebrovascular (mimic) conditions in emergency department (ED) settings. Design: Prospective clinical study (#NCT03050099) with up to three timed blood draws no more than 36 h following symptom onset. Plasma samples analysed by multiple reaction monitoring-mass spectrometry (MRM-MS). Participants: Totally 545 participants suspected of TIA enrolled in the EDs of two urban medical centres. Outcomes: 90-day, neurologist-adjudicated diagnosis of TIA informed by clinical and radiological investigations. Results: The final protein panel consists of 16 proteins whose patterns show differential abundance between TIA and mimic patients. Nine of the proteins were significant univariate predictors of TIA [odds ratio (95% confidence interval)]: L-selectin [0.726 (0.596–0.883)]; Insulin-like growth factor-binding protein 3 [0.727 (0.594–0.889)]; Coagulation factor X [0.740 (0.603–0.908)]; Serum paraoxonase/lactonase 3 [0.763 (0.630–0.924)]; Thrombospondin-1 [1.313 (1.081–1.595)]; Hyaluronan-binding protein 2 [0.776 (0.637–0.945)]; Heparin cofactor 2 [0.775 (0.634–0.947)]; Apolipoprotein B-100 [1.249 (1.037–1.503)]; and von Willebrand factor [1.256 (1.034–1.527)]. The scientific plausibility of the panel proteins is discussed. Conclusions: Our panel has the potential to assist ED physicians in distinguishing TIA from mimic patients.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipFunding for this study was provided by Genome British Columbia [grant number 4125-Penn], Genome Alberta [grant number 4125-Penn], and Genome Canada [grant number 4125-Penn]. The funding agencies had no role in the design of the study and collection, analysis, interpretation of data or writing of this manuscript. A. M. J. and C. H. B. are grateful to Genome Canada and Genome British Columbia for financial support for the University of Victoria-Genome BC Proteomics Centre (project codes 204PRO for operations and 214PRO for technology development). C. H. B. is also grateful for support from the Leading Edge Endowment Fund (University of Victoria), and from the Segal McGill Chair in Molecular Oncology at McGill University (Montreal, Quebec, Canada). C. H. B. is also grateful for support from the Warren Y. Soper Charitable Trust and the Alvin Segal Family Foundation to the Jewish General Hospital (Montreal, Quebec, Canada).en_US
dc.identifier.citationPenn, A. M., Bibok, M. B., Saly, V. K., Coutts, S. B., Lesperance, M. L., Balshaw, R. F., … Christoph H. Borchers & on behalf of the SpecTRA study group. (2018). Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study. Biomarkers, 23(4), 392-405. https://doi.org/10.1080/1354750X.2018.1434681en_US
dc.identifier.urihttps://doi.org/10.1080/1354750X.2018.1434681
dc.identifier.urihttp://hdl.handle.net/1828/12567
dc.language.isoenen_US
dc.publisherBiomarkersen_US
dc.subjectTIA
dc.subjecttransient ischaemic attack
dc.subjectTIA biomarkers
dc.subjectstroke biomarkers
dc.subjectstroke proteomic
dc.subjectplasma biomarkers
dc.subjectUVic Genome BC Proteomics Centre
dc.subject.departmentDepartment of Mathematics and Statistics
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleVerification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational studyen_US
dc.typeArticleen_US

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