Deformable versus rigid registration of PET/CT images for radiation treatment planning of head and neck and lung cancer patients: a retrospective dosimetric comparison

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dc.contributor.authorFortin, Dominique
dc.contributor.authorBasran, Parminder S
dc.contributor.authorBerrang, Tanya
dc.contributor.authorPeterson, David
dc.contributor.authorWai, Elaine S
dc.date.accessioned2015-06-03T23:38:36Z
dc.date.available2015-06-03T23:38:36Z
dc.date.copyright2014en_US
dc.date.issued2014-02-10
dc.descriptionBioMed Centralen_US
dc.description.abstractBackground: The purpose of this study is to evaluate the clinical impact of using deformable registration in tumor volume definition between separately acquired PET/CT and planning CT images. Methods: Ten lung and 10 head and neck cancer patients were retrospectively selected. PET/CT images were registered with planning CT scans using commercially available software. Radiation oncologists defined two sets of gross tumor volumes based on either rigidly or deformably registered PET/CT images, and properties of these volumes were then compared. Results: The average displacement between rigid and deformable gross tumor volumes was 1.8 mm (0.7 mm) with a standard deviation of 1.0 mm (0.6 mm) for the head and neck (lung) cancer subjects. The Dice similarity coefficients ranged from 0.76-0.92 and 0.76-0.97 for the head and neck and lung subjects, respectively, indicating conformity. All gross tumor volumes received at least 95% of the prescribed dose to 99% of their volume. Differences in the mean radiation dose delivered to the gross tumor volumes were at most 2%. Differences in the fraction of the tumor volumes receiving 100% of the radiation dose were at most 5%. Conclusions: The study revealed limitations in the commercial software used to perform deformable registration. Unless significant anatomical differences between PET/CT and planning CT images are present, deformable registration was shown to be of marginal value when delineating gross tumor volumes.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationFortin et al.: Deformable versus rigid registration of PET/CT images for radiation treatment planning of head and neck and lung cancer patients: a retrospective dosimetric comparison. Radiation Oncology 2014 9:50en_US
dc.identifier.urihttp://www.ro-journal.com/content/9/1/50
dc.identifier.urihttp:/dx.doi.org/10.1186/1748-717X-9-50
dc.identifier.urihttp://hdl.handle.net/1828/6226
dc.language.isoenen_US
dc.publisherRadiation Oncologyen_US
dc.rights.tempAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectDeformable
dc.subjectRegistration
dc.subjectPET/CT
dc.subjectTreatment
dc.subjectPlanning
dc.subject.departmentDepartment of Physics and Astronomy
dc.titleDeformable versus rigid registration of PET/CT images for radiation treatment planning of head and neck and lung cancer patients: a retrospective dosimetric comparisonen_US
dc.typeArticleen_US

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