Origin and emergence of microglia in the CNS—An interesting (hi)story of an eccentric cell

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dc.contributor.authorDermitzakis, Iasonas
dc.contributor.authorManthou, Maria Eleni
dc.contributor.authorMeditskou, Soultana
dc.contributor.authorTremblay, Marie-Ève
dc.contributor.authorPetratos, Steven
dc.contributor.authorZoupi, Lida
dc.contributor.authorBoziki, Marina
dc.contributor.authorKesidou, Evangelina
dc.contributor.authorSimeonidou, Constantina
dc.contributor.authorTheotokis, Paschalis
dc.date.accessioned2024-01-25T21:59:27Z
dc.date.available2024-01-25T21:59:27Z
dc.date.copyright2023en_US
dc.date.issued2023
dc.description.abstractMicroglia belong to tissue-resident macrophages of the central nervous system (CNS), representing the primary innate immune cells. This cell type constitutes ~7% of non-neuronal cells in the mammalian brain and has a variety of biological roles integral to homeostasis and pathophysiology from the late embryonic to adult brain. Its unique identity that distinguishes its “glial” features from tissue-resident macrophages resides in the fact that once entering the CNS, it is perennially exposed to a unique environment following the formation of the blood–brain barrier. Additionally, tissue-resident macrophage progenies derive from various peripheral sites that exhibit hematopoietic potential, and this has resulted in interpretation issues surrounding their origin. Intensive research endeavors have intended to track microglial progenitors during development and disease. The current review provides a corpus of recent evidence in an attempt to disentangle the birthplace of microglia from the progenitor state and underlies the molecular elements that drive microgliogenesis. Furthermore, it caters towards tracking the lineage spatiotemporally during embryonic development and outlining microglial repopulation in the mature CNS. This collection of data can potentially shed light on the therapeutic potential of microglia for CNS perturbations across various levels of severity.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationDermitzakis, I., Manthou, M. E., Meditskou, S., Tremblay, M-È., Petratos, S., Zoupi, L., ... Theotokis, P. (2023). Origin and emergence of microglia in the CNS—An interesting (hi)story of an eccentric cell. Current Issues in Molecular Biology, 45, 2609-2628. https://doi.org/10.3390/cimb45030171en_US
dc.identifier.urihttps://doi.org/10.3390/cimb45030171
dc.identifier.urihttp://hdl.handle.net/1828/15885
dc.language.isoenen_US
dc.publisherCurrent Issues in Molecular Biologyen_US
dc.subjectmicroglia
dc.subjectorigin
dc.subjectyolk sac
dc.subjectprogeny
dc.subjectmolecular cues
dc.subjectdevelopment
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleOrigin and emergence of microglia in the CNS—An interesting (hi)story of an eccentric cellen_US
dc.typeArticleen_US

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