The implication of a diversity of non-neuronal cells in disorders affecting brain networks

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dc.contributor.authorCarrier, Micaël
dc.contributor.authorDolhan, Kira
dc.contributor.authorBobotis, Bianca Caroline
dc.contributor.authorDesjardins, Michèle
dc.contributor.authorTremblay, Marie-Ève
dc.date.accessioned2024-02-14T17:16:10Z
dc.date.available2024-02-14T17:16:10Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.descriptionWe are grateful to our colleagues for sharing their insights and contributing to our manuscript through their expertise and time, especially Bob Chow for his critical revision and discussion.en_US
dc.description.abstractIn the central nervous system (CNS) neurons are classically considered the functional unit of the brain. Analysis of the physical connections and coactivation of neurons, referred to as structural and functional connectivity, respectively, is a metric used to understand their interplay at a higher level. A myriad of glial cell types throughout the brain composed of microglia, astrocytes and oligodendrocytes are key players in the maintenance and regulation of neuronal network dynamics. Microglia are the central immune cells of the CNS, able to affect neuronal populations in number and connectivity, allowing for maturation and plasticity of the CNS. Microglia and astrocytes are part of the neurovascular unit, and together they are essential to protect and supply nutrients to the CNS. Oligodendrocytes are known for their canonical role in axonal myelination, but also contribute, with microglia and astrocytes, to CNS energy metabolism. Glial cells can achieve this variety of roles because of their heterogeneous populations comprised of different states. The neuroglial relationship can be compromised in various manners in case of pathologies affecting development and plasticity of the CNS, but also consciousness and mood. This review covers structural and functional connectivity alterations in schizophrenia, major depressive disorder, and disorder of consciousness, as well as their correlation with vascular connectivity. These networks are further explored at the cellular scale by integrating the role of glial cell diversity across the CNS to explain how these networks are affected in pathology.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by research grants from the Canadian Institutes of Health Research (CIHR) and Natural Sciences and Engineering Research Council of Canada (NSERC) awarded to M-ÈT.MC is supported by a doctoral training award from Fonds de Recherche du Québec–Santé. M-ÈT is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition.en_US
dc.identifier.citationCarrier, M., Dolhan, K., Bobotis, B. C., Desjardins, M., & Tremblay, M-È. (2022). The implication of a diversity of non-neuronal cells in disorders affecting brain networks. Frontiers in Cellular Neuroscience, 16, https://doi.org/10.3389/fncel.2022.1015556en_US
dc.identifier.urihttps://doi.org/10.3389/fncel.2022.1015556
dc.identifier.urihttp://hdl.handle.net/1828/15996
dc.language.isoenen_US
dc.publisherFrontiers in Cellular Neuroscienceen_US
dc.subjectneurons
dc.subjectsynapses
dc.subjectstructural and functional connectivity
dc.subjectmicroglia
dc.subjectastrocytes
dc.subjectoligodendrocytes
dc.subjectvasculature
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Psychology
dc.subject.departmentDepartment of Biology
dc.titleThe implication of a diversity of non-neuronal cells in disorders affecting brain networksen_US
dc.typeArticleen_US

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