Development of Sustainable Konjac Glucomannan-Based Microcarriers for Cultivated Meat Production

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dc.contributor.authorSingh, Satinder
dc.contributor.supervisorAkbari, Mohsen
dc.date.accessioned2024-12-17T20:23:38Z
dc.date.available2024-12-17T20:23:38Z
dc.date.issued2024
dc.degree.departmentDepartment of Mechanical Engineering
dc.degree.levelMaster of Engineering MEng
dc.description.abstractThe global demand for sustainable alternatives to conventional meat production has promoted advancements in cultivated meat technologies, with scaffolding materials playing a key role in supporting cell growth and mimicking natural meat structures. This study investigates konjac glucomannan (KGM), a plant-based polysaccharide, as a biocompatible and cost-effective material for microcarrier generation in cell culture technologies. A method was developed to synthesize KGM hydrogels and fabricate microcarriers via controlled acidic degradation and crosslinking with epichlorohydrin (ECH) using a water-in-oil emulsion technique. The resulting microcarriers demonstrated excellent biocompatibility, mechanical stability, and a reticulated structure that may support cell adhesion and proliferation, competing with conventional dextran-based microcarriers while offering cost and sustainability benefits. These findings highlight KGM's potential as a cruelty-free microcarrier material for cultivated meat production and other biomedical applications, supporting the objectives of ethical innovation and global sustainability.
dc.description.scholarlevelGraduate
dc.identifier.urihttps://hdl.handle.net/1828/20848
dc.language.isoen
dc.rightsAvailable to the World Wide Web
dc.subjectKonjac Glucomannan (KGM)
dc.subjectMeat Cultivation
dc.subjectMicrofluidics, Batch-Emulsion
dc.subjectEpichlorohydrin (ECH)
dc.subjectMicrocarriers, Plant-Based Materials
dc.titleDevelopment of Sustainable Konjac Glucomannan-Based Microcarriers for Cultivated Meat Production
dc.typeproject

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