Fabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications

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dc.contributor.authorKo, Junghyuk
dc.contributor.authorMohtaram, Nima Khadem
dc.contributor.authorAhmed, Farid
dc.contributor.authorMontgomery, Amy
dc.contributor.authorCarlson, Michael
dc.contributor.authorLee, Patrick C.D.
dc.contributor.authorWillerth, Stephanie
dc.contributor.authorJun, Martin B.G.
dc.date.accessioned2016-05-24T12:31:35Z
dc.date.available2016-05-24T12:31:35Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.description.abstractHighly porous poly (ε-caprolactone) microfiber scaffolds can be fabricated using electrospinning for tissue engineering applications. Melt electrospinning produces such scaffolds by direct deposition of a polymer melt instead of dissolving the polymer in a solvent as performed during solution electrospinning. The objective of this study was to investigate the significant parameters associated with the melt electrospinning process that influence fiber diameter and scaffold morphology, including processing temperature, collection distance, applied voltage and nozzle size. The mechanical properties of these microfiber scaffolds varied with microfiber diameter. Additionally, the porosity of scaffolds was determined by combining experimental data with mathematical modeling. To test the cytocompatability of these fibrous scaffolds, we seeded neural progenitors derived from murine R1 embryonic stem cell lines onto these scaffolds where they could survive, migrate, and differentiate into neurons, demonstrating the potential of these melt electrospun scaffolds for tissue engineering applications.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors would like to acknowledge support from Natural Sciences and Engineering Research Council (NSERC) Discovery Grants. They would also like to acknowledge the Advanced Microscopy Facility at the University of Victoria.en_US
dc.identifier.citationKo, J., Mohtaram, N.K., Ahmed, F., Montgomery, A., Carlson, M., Lee, P.C.D. … Jun, M.B.G. (2014). Fabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications. Journal of Biomaterials Science—Polymer Edition, 25(1), 1-17.en_US
dc.identifier.urihttp://dx.doi.org/10.1080/09205063.2013.830913
dc.identifier.urihttp://hdl.handle.net/1828/7315
dc.language.isoenen_US
dc.publisherJournal of Biomaterials Science—Polymer Editionen_US
dc.subjectmelt electrospinning
dc.subjectmicrofibers
dc.subjectmicro structure
dc.subjectscaffolds
dc.subjectneural tissue engineering
dc.subjectstem cells
dc.subject.departmentDepartment of Mechanical Engineering
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleFabrication of poly (ε-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applicationsen_US
dc.typePostprinten_US

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