Gaucher Disease and Cancer: Concept and Controversy

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dc.contributor.authorChoy, Francis Y.M.
dc.contributor.authorCampbell, Tessa N.
dc.date.accessioned2017-10-23T17:51:17Z
dc.date.available2017-10-23T17:51:17Z
dc.date.copyright2011en_US
dc.date.issued2011-04
dc.description.abstractGaucher disease is an inherited disorder caused by a deficiency in the lysosomal hydrolase glucocerebrosidase. There is a wide spectrum of clinical presentations, with the most common features being hepatosplenomegaly, skeletal disease, and cytopenia. Gaucher disease has been classified into three broad phenotypes based upon the presence or absence of neurological involvement: Type 1 (nonneuronopathic), Type 2 (acute neuronopathic), and Type 3 (subacute neuronopathic). The two main treatment options include enzyme replacement therapy and substrate reduction therapy. Recently, discussion has escalated around the association of Gaucher disease and cancer, with conflicting reports as to whether Gaucher patients have an increased risk of malignancy. In this review, we present both the concept and controversy surrounding the association of Gaucher disease with cancer.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by Natural Sciences and Engineering Research Council Discovery Grant no. 138216-2009 to FYMC. T. N. Campbell of TNC Scientific Consulting received no financial remuneration.en_US
dc.identifier.citationChoy, F.Y.M. & Campbell, T.N. (2011). Gaucher Disease and Cancer: Concept and Controversy. International Journal of Cell Biology, 2011, 6 pages. http://dx.doi.org/10.1155/2011/150450en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2011/150450
dc.identifier.urihttp://hdl.handle.net/1828/8712
dc.language.isoenen_US
dc.publisherInternational Journal of Cell Biologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectCentre for Biomedical Research
dc.subject.departmentDepartment of Biology
dc.titleGaucher Disease and Cancer: Concept and Controversyen_US
dc.typeArticleen_US

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