Host–guest chemistry that directly targets lysine methylation: Synthetic host molecules as alternatives to bio-reagents
Date
2016
Authors
Hof, Fraser
Journal Title
Journal ISSN
Volume Title
Publisher
Chemical Communications
Abstract
Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.
Description
Keywords
Host-guest chemistry
Citation
Hof, F. (2016). Host–guest chemistry that directly targets lysine methylation: Synthetic host molecules as alternatives to bio-reagents. Chemical Communications, 52(66), 10093-10108. https://doi.org/10.1039/c6cc04771h