Host–guest chemistry that directly targets lysine methylation: Synthetic host molecules as alternatives to bio-reagents

dc.contributor.authorHof, Fraser
dc.date.accessioned2020-10-26T22:21:29Z
dc.date.available2020-10-26T22:21:29Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractPost-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipI am deeply grateful to all co-workers, colleagues, and collaborators, past and present.en_US
dc.identifier.citationHof, F. (2016). Host–guest chemistry that directly targets lysine methylation: Synthetic host molecules as alternatives to bio-reagents. Chemical Communications, 52(66), 10093-10108. https://doi.org/10.1039/c6cc04771hen_US
dc.identifier.urihttps://doi.org/10.1039/c6cc04771h
dc.identifier.urihttp://hdl.handle.net/1828/12266
dc.language.isoenen_US
dc.publisherChemical Communicationsen_US
dc.subjectHost-guest chemistryen_US
dc.titleHost–guest chemistry that directly targets lysine methylation: Synthetic host molecules as alternatives to bio-reagentsen_US
dc.typeArticleen_US

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