HIV Community Viral Load and Factors Associated With Elevated Viremia Among a Community-Based Sample of Men Who Have Sex With Men in Vancouver, Canada

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dc.contributor.authorMoore, David M.
dc.contributor.authorCui, Zishan
dc.contributor.authorLachowsky, Nathan J.
dc.contributor.authorRaymond, Henry F.
dc.contributor.authorRoth, Eric
dc.contributor.authorRich, Ashleigh
dc.contributor.authorSereda, Paul
dc.contributor.authorHoward, Terry
dc.contributor.authorMcFarland, Willi
dc.contributor.authorLal, Allan
dc.contributor.authorMontaner, Julio
dc.contributor.authorCorneil, Trevor
dc.contributor.authorHogg, Robert S.
dc.date.accessioned2022-08-29T23:07:08Z
dc.date.available2022-08-29T23:07:08Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.descriptionThe authors would like to thank the Momentum Study participants, office staff and community advisory board, as well as our community partner agencies, the Health Initiative for Men, YouthCo HIV and Hep C Society, and the Positive Living Society of BC.en_US
dc.description.abstractBackground—We developed estimates of community viral load (VL) and risk factors for unsuppressed VL from a cross-sectional study of men who have sex with men (MSM) in Vancouver, Canada. Methods—MSM were recruited from February 25, 2012 – February 28, 2014 using Respondent- Driven Sampling (RDS). Participants completed a computer assisted self-interview questionnaire and a nurse-administered point-of-care HIV test. For HIV positive participants, we conducted VL and CD4 cell counts. We used RDS-weighted analysis to obtain population estimates of key variables and multivariable logistic regression to examine factors associated with having a VL ≥200 copies/mL among HIV-positive participants. Results—We recruited 719 participants, of whom 119 (16.6%) were seeds. Our estimate of the population HIV prevalence was 23.4% (95% CI 15.8 – 31.0%) after RDS-adjustments. We estimated that 18.6% (95% confidence interval [CI] 8.8 – 30.4%) of HIV-positive MSM in Vancouver had a VL ≥200 copies/mL. Having an unsuppressed VL was associated with non- Caucasian ethnicity (adjusted odds ratio [AOR]= 4.34; 95% CI 1.67 – 11.1); an annual income of <$15,000 CAD (AOR=6.43; 95%CI 2.08–19.9); using GHB in the previous six months (AOR=4.85; 95%CI 1.79–13.2); unprotected anal intercourse with a known HIV negative or unknown serostatus partner (AOR=3.13; 95%CI 1.10–8.90); and disclosing one’s HIV serostatus ≥50% of the time (AOR=7.04; 95%CI 1.01–49.1). Conclusion—Despite a high prevalence of HIV, we estimated that a small proportion of HIV positive MSM have undiagnosed HIV and unsuppressed VL. Our results highlight the importance of continued work to address health inequities using a social determinants of health framework.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis study was funded through the National Institute on Drug Abuse (Grant #R01DA031055-01A1) and the Canadian Institutes for Health Research (Grant # MOP-107544). DMM is supported by a Scholar Award from the Michael Smith Foundation for Health Research. NL is supported by a postdoctoral fellowship award from the Canadian HIV Clinical Trials Network and the Canadian Foundation for AIDS Research. JM is supported with grants paid to his institution by the British Columbia Ministry of Health and by the US National Institutes of Health (R01DA036307). He has also received limited unrestricted funding, through his institution, from Abbvie, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck, and ViiV Healthcare.en_US
dc.identifier.citationMoore, D. M., Cui, Z., Lachowsky, N., Raymond, H. F., Roth, E., Rich, A., Sereda, P., Howard, T., McFarland, W., Lal, A., Montaner, J., Corneil, T., & Hogg, R. S. (2016). “HIV Community Viral Load and Factors Associated With Elevated Viremia Among a Community-Based Sample of Men Who Have Sex With Men in Vancouver, Canada.” Journal of Acquired Immune Deficiency Syndromes, 72(1), 87-95. https://doi.org/10.1097/QAI.0000000000000934en_US
dc.identifier.urihttps://doi.org/10.1097/QAI.0000000000000934
dc.identifier.urihttp://hdl.handle.net/1828/14152
dc.language.isoenen_US
dc.publisherJournal of Acquired Immune Deficiency Syndromesen_US
dc.subjectmen who have sex with men (MSM)
dc.subjectcommunity viral load
dc.subjecttreatment as prevention
dc.subjectrisky sex
dc.subject.departmentDepartment of Anthropology
dc.titleHIV Community Viral Load and Factors Associated With Elevated Viremia Among a Community-Based Sample of Men Who Have Sex With Men in Vancouver, Canadaen_US
dc.typePostprinten_US

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