Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus

Simple item page
dc.contributor.authorPeñasco, Sara
dc.contributor.authorRico-Barrio, Irantzu
dc.contributor.authorPuente, Nagore
dc.contributor.authorGómez-Urquijo, Sonia María
dc.contributor.authorFontaine, Christine J.
dc.contributor.authorEgaña-Huguet, Jon
dc.contributor.authorAchicallende, Svein
dc.contributor.authorRamos, Almudena
dc.contributor.authorReguero, Leire
dc.contributor.authorElezgarai, Izaskun
dc.contributor.authorNahirney, Patrick C.
dc.contributor.authorChristie, Brian R.
dc.contributor.authorGrandes, Pedro
dc.date.accessioned2019-06-17T16:25:13Z
dc.date.available2019-06-17T16:25:13Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractThe endocannabinoid system modulates synaptic plasticity in the hippocampus, but a link between long-term synaptic plasticity and the type 1 cannabinoid (CB1) receptor at medial perforant path (MPP) synapses remains elusive. Here, immuno-electron microscopy in adult mice showed that ∼26% of the excitatory synaptic terminals in the middle 1/3 of the dentate molecular layer (DML) contained CB1 receptors, and field excitatory postsynaptic potentials evoked by MPP stimulation were inhibited by CB1 receptor activation. In addition, MPP stimulation at 10 Hz for 10 min triggered CB1 receptor-dependent excitatory long-term depression (eCB-eLTD) at MPP synapses of wild-type mice but not on CB1-knockout mice. This eCB-eLTD was group I mGluR-dependent, required intracellular calcium influx and 2-arachydonoyl-glycerol (2-AG) synthesis but did not depend on N-methyl-d-aspartate (NMDA) receptors. Overall, these results point to a functional role for CB1 receptors with eCB-eLTD at DML MPP synapses and further involve these receptors in memory processing within the adult brain.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by MINECO/FEDER, UE (grant number SAF2015-65034-R to PG); The Basque Government (grant number BCG IT764-13 to PG); Red de Trastornos Adictivos, Instituto de Salud Carlos III (ISC-III) and European Regional Development Funds-European Union (ERDF-EU; grant RD16/0017/0012 to PG); PhD contract from MINECO (BES-2013-065057 to SP); Vanier Canada Graduate Scholarship (NSERC to CJF).en_US
dc.identifier.citationPeñasco , S., Rico-Barrio, I., Puente, N., Gómez-Urquijo, S.M., Fontaine, C.J., Egaña-Huguet, J., … Grandes, P. (2019). Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus. Neuropharmacology, 153, 32-40. https://doi.org/10.1016/j.neuropharm.2019.04.020en_US
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2019.04.020
dc.identifier.urihttp://hdl.handle.net/1828/10924
dc.language.isoenen_US
dc.publisherNeuropharmacologyen_US
dc.subjectCB1 receptor
dc.subject2-AG
dc.subjectElectrophysiology
dc.subjectExcitatory synapses
dc.subjectLong-term depression
dc.subjectHippocampus
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.titleEndocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrusen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Penasco_Sara_Neuropharm_2019.pdf
Size:
1.93 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.