The Structural Determinants behind the Epigenetic Role of Histone Variants

Simple item page
dc.contributor.authorCheema, Majinder S.
dc.contributor.authorAusio, Juan
dc.date.accessioned2018-12-19T05:53:23Z
dc.date.available2018-12-19T05:53:23Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.description.abstractHistone variants are an important part of the histone contribution to chromatin epigenetics. In this review, we describe how the known structural differences of these variants from their canonical histone counterparts impart a chromatin signature ultimately responsible for their epigenetic contribution. In terms of the core histones, H2A histone variants are major players while H3 variant CenH3, with a controversial role in the nucleosome conformation, remains the genuine epigenetic histone variant. Linker histone variants (histone H1 family) haven’t often been studied for their role in epigenetics. However, the micro-heterogeneity of the somatic canonical forms of linker histones appears to play an important role in maintaining the cell-differentiated states, while the cell cycle independent linker histone variants are involved in development. A picture starts to emerge in which histone H2A variants, in addition to their individual specific contributions to the nucleosome structure and dynamics, globally impair the accessibility of linker histones to defined chromatin locations and may have important consequences for determining different states of chromatin metabolismen_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by a Canadian Institutes of Health Research (CIHR) (MOP-130417) grant.en_US
dc.identifier.citationCheema, M.S. & Ausio, J. (2015). The Structural Determinants behind the Epigenetic Role of Histone Variants. Genes, 6(3), 685-713. https://doi.org/10.3390/genes6030685en_US
dc.identifier.urihttps://doi.org/10.3390/genes6030685
dc.identifier.urihttp://hdl.handle.net/1828/10428
dc.language.isoenen_US
dc.publisherGenesen_US
dc.subjectchromatin
dc.subjectepigenetics
dc.subjecthistones
dc.subjecthistone variants
dc.subjectnucleosome
dc.subjectCentre for Biomedical Research
dc.subject.departmentDepartment of Biology
dc.titleThe Structural Determinants behind the Epigenetic Role of Histone Variantsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ausio_J_Genes_2015.pdf
Size:
3.81 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.