Combining protein-based biomaterials with stem cells for spinal cord injury repair
Date
2014
Authors
Montgomery, A
Agbay, A
Edgar, JM
Gabers, N
Gomez, J
Mohtaram, NK
King, C
Mitchell, A
Rajwani, A
Rattray, D
Journal Title
Journal ISSN
Volume Title
Publisher
OA Publishing London
Abstract
Introduction
Protein-based biomaterials can be
combined with stem cells to develop
therapies that aid in the regeneration
of injured spinal cords. These
approaches use various protein scaffolds
to support the survival and differentiation
of implanted stem cellderived
populations into functional
neurons and glial cells with the aim
of overcoming the inhibitory scarring
that restricts cell regrowth after spinal
cord injury. The following review
evaluates two key protein-based
biomaterials–fibrin and collagen–in
combination with both pluripotent
and multipotent stem cells as strategies
for spinal cord injury repair. Recent
studies on the protein network
of decellularised extracellular matrix
are also highlighted as an exciting
area for future work.
Conclusion
The combination of protein-based
biomaterials with stem cells shows
significant promise as a strategy for
spinal cord injury repair.
Description
Keywords
Citation
Montgomery A, Agbay A, Edgar JM, Gabers N, Gomez J, Mohtaram NK, et al. Combining protein-based biomaterials with stem cells for spinal cord injury repair. OA Stem Cells 2014 Jan 18;2(1):1.