Combining protein-based biomaterials with stem cells for spinal cord injury repair

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dc.contributor.authorMontgomery, A
dc.contributor.authorAgbay, A
dc.contributor.authorEdgar, JM
dc.contributor.authorGabers, N
dc.contributor.authorGomez, J
dc.contributor.authorMohtaram, NK
dc.contributor.authorKing, C
dc.contributor.authorMitchell, A
dc.contributor.authorRajwani, A
dc.contributor.authorRattray, D
dc.contributor.authorRobinson, M
dc.contributor.authorShapka, A
dc.contributor.authorSun, L
dc.contributor.authorWong, A
dc.contributor.authorWillerth, Stephanie
dc.date.accessioned2015-06-11T22:20:50Z
dc.date.available2015-06-11T22:20:50Z
dc.date.copyright2014en_US
dc.date.issued2014
dc.description.abstractIntroduction: Protein-based biomaterials can be combined with stem cells to develop therapies that aid in the regeneration of injured spinal cords. These approaches use various protein scaffolds to support the survival and differentiation of implanted stem cell-derived populations into functional neurons and glial cells with the aim of overcoming the inhibitory scarring that restricts cell regrowth after spinal cord injury. The following review evaluates two key protein-based biomaterials–fibrin and collagen–in combination with both pluripotent and multipotent stem cells as strategies for spinal cord injury repair. Recent studies on the protein network of decellularised extracellular matrix are also highlighted as an exciting area for future work. Conclusion: The combination of protein-based biomaterials with stem cells shows significant promise as a strategy for spinal cord injury repair.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationMontgomery A, Agbay A, Edgar JM, Gabers N, Gomez J, Mohtaram NK, et al. Combining protein-based biomaterials with stem cells for spinal cord injury repair. OA Stem Cells 2014 Jan 18;2(1):1.en_US
dc.identifier.urihttps://www.oapublishinglondon.com/article/1160#
dc.identifier.urihttp://hdl.handle.net/1828/6257
dc.language.isoenen_US
dc.publisherOA Publishing Londonen_US
dc.titleCombining protein-based biomaterials with stem cells for spinal cord injury repairen_US
dc.typeArticleen_US

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