Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins?

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dc.contributor.authorWicki-Stordeur, Leigh E.
dc.contributor.authorSwayne, Leigh Anne
dc.date.accessioned2015-08-21T18:57:07Z
dc.date.available2015-08-21T18:57:07Z
dc.date.copyright2012en_US
dc.date.issued2012-04-27
dc.description.abstractThe birth of new neurons from unspecialized neural stem and progenitor cells surrounding the lateral ventricles occurs throughout postnatal life. This process, termed neurogenesis, is complex and multistepped, encompassing several types of cellular behaviours, such as proliferation, differentiation, and migration. These behaviours are influenced by numerous factors present in the unique, permissive microenvironment. A major cellular mechanism for sensing the plethora of environmental cues directing this process is the presence of different channel forming proteins spanning the plasma membrane. So-called large pore membrane channels, which are selective for the passage of specific types of small molecules and ions, are emerging as an important subgroup of channel proteins. Here, we focus on the roles of three such large pore channels, aquaporin 4, connexin 43, and pannexin 1. We highlight both their independent functions as well as the accumulating evidence for crosstalk between them.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada; Victoria Foundation Willa and Ella Dawson Fund grant; University of Victoriaen_US
dc.identifier.citationWicki-Stordeur, L. & Swayne, L. 2012, "Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins?", STEM CELLS INTERNATIONAL, vol. 2012, Article ID 454180.en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2012/454180
dc.identifier.urihttp://hdl.handle.net/1828/6470
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.subjectIsland Medical Program
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Biology
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titleLarge Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins?en_US
dc.typeArticleen_US

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