Effect of triploidy on liver gene expression in coho salmon (Oncorhynchus kisutch) under different metabolic states

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dc.contributor.authorChristensen, Kris A.
dc.contributor.authorSakhrani, Dionne
dc.contributor.authorRondeau, Eric B.
dc.contributor.authorRichards, Jeffery
dc.contributor.authorKoop, Ben F.
dc.contributor.authorDevlin, Robert H.
dc.date.accessioned2020-11-30T22:08:01Z
dc.date.available2020-11-30T22:08:01Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractTriploid coho salmon are excellent models for studying gene dosage and the effects of increased cell volume on gene expression. Triploids have an additional haploid genome in each cell and have fewer but larger cells than diploid coho salmon to accommodate the increased genome size. Studying gene expression in triploid coho salmon provides insight into how gene expression may have been affected after the salmonid-specific genome duplication which occurred some 90 MYA. Triploid coho salmon are sterile and consequently can live longer and grow larger than diploid congeners in many semelparous species (spawning only once) because they never reach maturity and post-spawning mortality is averted. Triploid fishes are also of interest to the commercial sector (larger fish are more valuable) and to fisheries management since sterile fish can potentially minimize negative impacts of escaped fish in the wild.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipFunding for this research was provided by the Canadian Regulatory System for Biotechnology (RHD). The funding body did not participate in the design of the study, sample collection, analysis, or in the writing of the manuscript.en_US
dc.identifier.citationChristensen, K. A., Sakhrani, D., Rondeau, E. B., Richards, J., Koop, B. F., Devlin, R. H. (2019). Effect of triploidy on liver gene expression in coho salmon (Oncorhynchus kisutch) under different metabolic states. BMC Genomics, 20(1). https://doi.org/10.1186/s12864-019-5655-8en_US
dc.identifier.urihttps://doi.org/10.1186/s12864-019-5655-8
dc.identifier.urihttp://hdl.handle.net/1828/12408
dc.language.isoenen_US
dc.publisherBMC Genomicsen_US
dc.subjectPloidy
dc.subjectTriploid
dc.subjectGene dosage
dc.subjectTransgenic
dc.subjectRNA-seq
dc.subjectSalmonid
dc.subjectGrowth hormone
dc.subject.departmentDepartment of Biology
dc.titleEffect of triploidy on liver gene expression in coho salmon (Oncorhynchus kisutch) under different metabolic statesen_US
dc.typeArticleen_US

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