Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements

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dc.contributor.authorWicki-Stordeur, Leigh E
dc.contributor.authorSwayne, Leigh Anne
dc.date.accessioned2015-03-27T19:44:05Z
dc.date.available2015-03-27T19:44:05Z
dc.date.copyright2013en_US
dc.date.issued2013-08-21
dc.descriptionBioMed Centralen_US
dc.description.abstractBackground: Pannexins (Panxs) are relatively newly discovered large-pore ion and metabolite permeable channels. Although no proteomics-based interactome has yet been published, Panx1 has been demonstrated to interact with actin in an ectopic expression system. This interaction affects both Panx1 plasma membrane stability as well as cytoskeletal remodelling. The current study builds on our recent discovery of Panx1 expression in ventricular zone (VZ) neural stem and progenitor cells (NSC/NPCs), and on the demonstrated interaction of Panx1 with the cytoskeleton. Findings: Here we demonstrate that Panx1 also plays roles in two additional cell behaviours associated with neurogenesis, including cell migration and neurite extension. Furthermore, we confirm an endogenous interaction between actin and Panx1, and identify a new interaction with actin-related protein 3, an actin cytoskeleton-modulating protein. Conclusions: This study further establishes the importance of Panx1 in the cell biology of NSC/NPCs and strengthens and expands our knowledge of Panx1 interactions with the cytoskeleton.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipOperating support for this work came from a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant, a Victoria Foundation Willard and Elva Dawson fund grant, and a University of Victoria laboratory start-up grant awarded to LAS. We also thank the Canadian Foundation for Innovation Leaders Opportunity Fund, and the British Columbia Knowledge and Development Fund for supporting the purchase of a confocal microscope that was essential to this work. LWS is supported by an NSERC Vanier Canada Graduate Scholarship, a Howard E. Petch Research Scholarship and an Edythe Hembroff-Schleicher Graduate Scholarship.en_US
dc.identifier.citationWicki-Stordeur and Swayne: Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements. Cell Communication and Signaling 2013 11:62en_US
dc.identifier.urihttp://www.biosignaling.com/content/11/1/62
dc.identifier.urihttp://dx.doi.org/10.1186/1478-811X-11-62
dc.identifier.urihttp://hdl.handle.net/1828/5933
dc.language.isoenen_US
dc.publisherCell Communication and Signalingen_US
dc.rights.tempAttribution-NonCommercial-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/ca/*
dc.subjectIsland Medical Program
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Biology
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titlePanx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elementsen_US
dc.typeArticleen_US

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