Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity
| dc.contributor.author | Patten, Anna R. | |
| dc.contributor.author | Gil-Mohapel, Joana | |
| dc.contributor.author | Wortman, Ryan C. | |
| dc.contributor.author | Noonan, Athena | |
| dc.contributor.author | Brocardo, Patricia S. | |
| dc.contributor.author | Christie, Brian R. | |
| dc.date.accessioned | 2020-10-13T21:23:55Z | |
| dc.date.available | 2020-10-13T21:23:55Z | |
| dc.date.copyright | 2013 | en_US |
| dc.date.issued | 2013 | |
| dc.description.abstract | Fetal alcohol spectrum disorders occur when a mother drinks during pregnancy and can greatly influence synaptic plasticity and cognition in the offspring. In this study we determined whether there are periods during brain development that are more susceptible to the effects of ethanol exposure on hippocampal synaptic plasticity. In particular, we evaluated how the ability to elicit long-term potentiation (LTP) in the hippocampal dentate gyrus (DG) was affected in young adult rats that were exposed to ethanol during either the 1st, 2nd, or 3rd trimester equivalent. As expected, the effects of ethanol on young adult DG LTP were less severe when exposure was limited to a particular trimester equivalent when compared to exposure throughout gestation. In males, ethanol exposure during the 1st, 2nd or 3rd trimester equivalent did not significantly reduce LTP in the DG. In females, ethanol exposure during either the 1st or 2nd trimester equivalents did not impact LTP in early adulthood, but following exposure during the 3rd trimester equivalent alone, LTP was significantly increased in the female DG. These results further exemplify the disparate effects between the ability to elicit LTP in the male and female brain following perinatal ethanol exposure (PNEE). | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | A.P. is funded by a NeuroDevNet Scholarship and a Graduate Fellowship from the University of Victoria. J.G.M. and P.S.B. acknowledge post-doctoral funding from the Michael Smith Foundation for Health Research (MSFHR, Canada), and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; National Counsel of Technological and Scientific Development, Brazil), respectively. B.R.C. is a Michael Smith Senior Scholar and is supported by grants from the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), MSFHR, and the Canada Foundation for Innovation (CFI). The authors would like to thank Jennifer Graham for technical support and help with designing and implementing the feeding schedule for the animals used in this study and Scott Sawchuk for technical support during electrophysiological recordings. | en_US |
| dc.identifier.citation | Patten, A. R., Gil-Mohapel, J., Wortman, R. C., Noonan, A., Brocardo, P. S., & Christie, B. R. (2013). Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity. Brain Sciences, 3(3), 1076-1094. https://doi.org/10.3390/brainsci3031076. | en_US |
| dc.identifier.uri | https://doi.org/10.3390/brainsci3031076 | |
| dc.identifier.uri | http://hdl.handle.net/1828/12196 | |
| dc.language.iso | en | en_US |
| dc.publisher | Brain Sciences | en_US |
| dc.subject | dentate gyrus | |
| dc.subject | ethanol | |
| dc.subject | fetal alcohol spectrum disorders | |
| dc.subject | fetal alcohol syndrome | |
| dc.subject | hippocampus | |
| dc.subject | long-term potentiation | |
| dc.subject | synaptic plasticity | |
| dc.subject | vulnerability period | |
| dc.subject | Island Medical Program | |
| dc.subject.department | Division of Medical Sciences | |
| dc.subject.department | School of Medical Sciences | |
| dc.subject.department | Department of Biology | |
| dc.title | Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity | en_US |
| dc.type | Article | en_US |