Analysis of the conservation of synteny between Fugu and human chromosome 12

Date

2003-05

Authors

Wilson, Michael D
Chevrette, Mario
Koop, Ben F.
Sinnett, Daniel
Montpetit, Alexandre

Journal Title

Journal ISSN

Volume Title

Publisher

BMC Genomics

Abstract

Background The pufferfish Fugu rubripes (Fugu) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and Fugu genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.

Description

BioMed Central

Keywords

Citation

Montpetit, A., Wilson, M., Chevrette, M., Koop, B., & Sinnett, D. (2003). Analysis of the conservation of synteny between fugu and human chromosome 12. BMC Genomics, 4(1), 30. Retrieved from http://www.biomedcentral.com/1471-2164/4/30