Analysis of the conservation of synteny between Fugu and human chromosome 12
Date
2003-05
Authors
Wilson, Michael D
Chevrette, Mario
Koop, Ben F.
Sinnett, Daniel
Montpetit, Alexandre
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Genomics
Abstract
Background
The pufferfish Fugu rubripes (Fugu) with its compact genome is increasingly recognized as an important vertebrate model for comparative genomic studies. In particular, large regions of conserved synteny between human and Fugu genomes indicate its utility to identify disease-causing genes. The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified.
Description
BioMed Central
Keywords
Citation
Montpetit, A., Wilson, M., Chevrette, M., Koop, B., & Sinnett, D. (2003). Analysis of the conservation of synteny between fugu and human chromosome 12. BMC Genomics, 4(1), 30. Retrieved from http://www.biomedcentral.com/1471-2164/4/30