White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults

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dc.contributor.authorHalliday, Drew W. R.
dc.contributor.authorGawryluk, Jodie R.
dc.contributor.authorGarcia-Barrera, Mauricio A.
dc.contributor.authorMacDonald, Stuart W. S.
dc.date.accessioned2021-08-20T21:58:43Z
dc.date.available2021-08-20T21:58:43Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.description.abstractInconsistency of performance across neuropsychological testing instruments (dispersion) shows sensitivity to acquired injury and neurodegenerative pathology in older adults. The underlying neural correlates have remained speculative however, in spite of known white matter degradation seen in conjunction with elevated inconsistency in related operationalizations of intraindividual variability. Consistently, these operationalizations have controlled for artifactual age-related variance to increase measurement sensitivity of CNS dysfunction. In this study, dispersion was examined alongside composite scores of memory and executive functioning from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Forty-four healthy older adults (M = 72.0, SD = 6.4) underwent Diffusion Tensor Imaging (DTI) and neuropsychological testing spanning a range of cognitive domains. The results replicated previous findings, demonstrating reduced microstructural integrity with advanced age and increased integrity in high memory and executive functioning performers, across all major white matter tracts. With age first regressed from the composite scores, significant associations remained between greater executive functioning scores and greater microstructural integrity in the genu of the corpus callosum, right anterior corona radiata, anterior, posterior and rentrolenticular parts of right internal capsule, as well as right posterior thalamic radiation. With age regressed from the dispersion scores, greater values were primarily associated with decreased white matter integrity in the body and genu of corpus callosum, anterior corona radiata bilaterally and left superior longitudinal fasciculus. Dispersion is easily computed across speeded and accuracy-based measures and shows promise in detecting white matter damage, beyond that seen in the typical aging process. This appears to be the first investigation of neural correlates associated with increased dispersion.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by a Canada Graduate Scholarship from the Canadian Institutes of Health Research (DH). Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI; National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH- 12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research and Development, LLC.; Johnson and Johnson Pharmaceutical Research and Development LLC.; Lumosity; Lundbeck; Merck and Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health5. The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer’s Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California.en_US
dc.identifier.citationHalliday, D.W.R., Gawryluk. J.R., Garcia-Barrera, M.A., & MacDonald, S.W.S. (2019). White Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adults. Frontiers in Human Neuroscience, 13(352). https://doi.org/10.3389/fnhum.2019.00352en_US
dc.identifier.urihttps://doi.org/10.3389/fnhum.2019.00352
dc.identifier.urihttp://hdl.handle.net/1828/13294
dc.language.isoenen_US
dc.publisherFrontiers in Human Neuroscienceen_US
dc.subjectdiffusion tensor imaging (DTI)
dc.subjectintraindividual variability (IIV)
dc.subjectdispersion
dc.subjectAlzheimer's Disease
dc.subjectNeuroimaging Initative (ADNI)
dc.subjectcognitive aging
dc.subjectneuropsychological assessment
dc.subject.departmentDepartment of Psychology
dc.titleWhite Matter Integrity Is Associated With Intraindividual Variability in Neuropsychological Test Performance in Healthy Older Adultsen_US
dc.typeArticleen_US

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