Microglial hetergeneity in aging and Alzheimer's disease: Is sex relevant?

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dc.contributor.authorDelage, Charlotte Isabelle
dc.contributor.authorŠimončičová, Eva
dc.contributor.authorTremblay, Marie-Ève
dc.date.accessioned2021-05-18T20:22:20Z
dc.date.available2021-05-18T20:22:20Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractNeurodegenerative diseases and their associated cognitive decline are known to be more prevalent during aging. Recent evidence has uncovered the role of microglia, the immunocompetent cells of the brain, in dysfunctions linked to neurodegenerative diseases such as is Alzheimer's disease (AD). Similar to other pathologies, AD is shown to be sex-biased, with females being more at risk compared to males. While the mechanisms driving this prevalence are still unclear, emerging data suggest the sex differences present in microglia throughout life might lead to different responses of these cells in both health and disease. Furthermore, microglial cells have recently been recognized as a deeply heterogeneous population, with multiple subsets and/or phenotypes stemming from diverse parameters such as age, sex or state of health. Therefore, this review discusses microglial heterogeneity during aging in both basal conditions and AD with a focus on existing sex differences in this process.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationDelage, C. I., Šimončičová, E., & Tremblay, M. (2021). Microglial heterogeneity in aging and Alzheimer’s disease: Is sex relevant? Journal of Pharmacological Sciences, 146(3), 169-181. https://doi.org/10.1016/j.jphs.2021.03.006.en_US
dc.identifier.urihttps://doi.org/10.1016/j.jphs.2021.03.006
dc.identifier.urihttp://hdl.handle.net/1828/12978
dc.language.isoenen_US
dc.publisherJournal of Pharmacological Sciencesen_US
dc.subjectAgingen_US
dc.subjectNeurodegenerationen_US
dc.subjectSex differencesen_US
dc.subjectMicrogliaen_US
dc.subjectAlzheimer's diseaseen_US
dc.titleMicroglial hetergeneity in aging and Alzheimer's disease: Is sex relevant?en_US
dc.typeArticleen_US

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