New Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequence

Simple item page
dc.contributor.authorPoblete, Horacio
dc.contributor.authorAgarwal, Anirudh
dc.contributor.authorThomas, Suma S.
dc.contributor.authorBohne, Cornelia
dc.contributor.authorRavichandran, Ranjithkumar
dc.contributor.authorPhopase, Jaywant
dc.contributor.authorComer, Jeffrey
dc.contributor.authorAlarcon, Emilio I.
dc.date.accessioned2020-08-31T21:44:07Z
dc.date.available2020-08-31T21:44:07Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractWe studied the interaction of four new pentapeptides with spherical silver nanoparticles. Our findings indicate that the combination of the thiol in Cys and amines in Lys/Arg residues is critical to providing stable protection for the silver surface. Molecular simulation reveals the atomic scale interactions that underlie the observed stabilizing effect of these peptides, while yielding qualitative agreement with experiment for ranking the affinity of the four pentapeptides for the silver surface.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors thank Zak Hughes for providing the Gromacs parameter files for the AgNPs force field. This work was supported by NSERC Discovery (EIA) and University of Ottawa Heart Institute (EIA). This work was also supported by the Project FONDECYT 3140288 (HP). HP and JC were partially supported by the Kansas Bioscience Authority funds to the Institute of Computational Comparative Medicine (ICCM) at Kansas State University and to the Nanotechnology Innovation Center of Kansas State University (NICKS). The Kansas State University Global Food Systems Innovation Program (383GFS) provided further support (HP and JC). Computing for this project was performed on the Beocat Research Cluster at Kansas State University, which is funded in part by NSF grants CNS-1006860, EPS-1006860, and EPS-0919443. Additional computer time was generously provided by the Extreme Science and Engineering Discovery Environment (XSEDE) under request TGMCB150036. XSEDE is supported by National Science Foundation grant number ACI-1053575. The work at the University of Victoria was supported by an NSERC Discovery Grant (RGPIN-121389-2012). The work at Linköping University was supported by Swedish Research Council (dnr 621-2012-4286).en_US
dc.identifier.citationPoblete, H., Agarwal, A., Thomas, S. S., Bohne, C., Ravichandran, R., Phopase, J., Comer, J., & Alarcon, E. I. (2018). New Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequence. Langmuir, 32, 265-273. https://doi.org/10.1021/acs.langmuir.5b03601.en_US
dc.identifier.urihttps://doi.org/10.1021/acs.langmuir.5b03601
dc.identifier.urihttp://hdl.handle.net/1828/12064
dc.language.isoenen_US
dc.publisherLangmuiren_US
dc.subjectFree energy
dc.subjectMetal nanoparticles
dc.subjectPeptides and proteins
dc.subjectMonomers
dc.subjectNanoparticles
dc.subject.departmentDepartment of Chemistry
dc.titleNew Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequenceen_US
dc.typePostprinten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Poblete_Horacio_Langmuir_2016.pdf
Size:
8.25 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.