Population-Level Sexual Mixing According to HIV Status and Preexposure Prophylaxis Use Among Men Who Have Sex With Men in Montreal, Canada: Implications for HIV Prevention

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dc.contributor.authorWang, Linwei
dc.contributor.authorMoqueet, Nasheed
dc.contributor.authorLambert, Gilles
dc.contributor.authorGrace, Daniel
dc.contributor.authorRodrigues, Ricky
dc.contributor.authorCox, Joseph
dc.contributor.authorLachowsky, Nathan J.
dc.contributor.authorNoor, Syed W.
dc.contributor.authorArmstrong, Heather L.
dc.contributor.authorTan, Darrell H. S.
dc.contributor.authorBurchell, Ann N.
dc.contributor.authorMa, Huiting
dc.contributor.authorApelian, Herak
dc.contributor.authorKnight, Jesse
dc.contributor.authorMessier-Peet, Marc
dc.contributor.authorJollimore, Jody
dc.contributor.authorBaral, Stefan
dc.contributor.authorHart, Trevor A.
dc.contributor.authorMoore, David M.
dc.contributor.authorMishra, Sharmistha
dc.date.accessioned2022-03-16T16:26:44Z
dc.date.available2022-03-16T16:26:44Z
dc.date.copyright2019en_US
dc.date.issued2019
dc.descriptionThe authors thank the Engage-Montreal office staff and community engagement committee members, as well as their community partner agencies.en_US
dc.description.abstractUsing cross-sectional survey data (Engage, 2017–2018) from 1,137 men who have sex with men, ≥16 years old, in Montreal, we compared observed human immunodeficiency virus (HIV) seroconcordance in previous- 6-months’ sexual partnerships with what would have been observed by chance if zero individuals serosorted. Of 5 recent partnerships where both individuals were HIV-negative, we compared observed concordance in preexposure prophylaxis (PrEP) use with the counterfactual if zero individuals selected partners based on PrEP use. We estimated the concordance by chance using a balancing-partnerships approach assuming proportionate mixing. HIV-positive respondents had a higher proportion of HIV-positive partners (66.4%, 95% confidence interval (CI): 64.0, 68.6) than by chance (23.9%, 95% CI: 23.1, 24.7). HIV-negative respondents (both on and not on PrEP) had higher proportions of HIV-negative partners (82.9% (95% CI: 81.1, 84.7) and 90.7% (95% CI: 89.6, 91.7), respectively) compared with by chance (76.1%, 95% CI: 75.3, 76.9); however, those on PrEP had a higher proportion of HIV-positive partners than those not on PrEP (17.1% (95% CI: 15.3, 18.9) vs. 9.3% (95% CI: 8.3, 10.4). Those on PrEP also had a higher proportion of partners on PrEP among their HIV-negative partners (50.6%, 95% CI: 42.5, 58.8) than by chance (28.5%, 95% CI: 27.5, 29.4).The relationship between PrEP and sexual-mixing patterns demonstrated by less population-level serosorting among those on PrEP and PrEP-matching warrants consideration during PrEP roll-out.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipEngage-Montreal was supported by the Canadian Institutes of Health Research (grant TE2-138299), Canadian Institutes of Health Research Canadian HIV Trials Network (grant CTN 300), Canadian Foundation for AIDS Research (Engage), Canadian Blood Services (grant MSM2017LP-OD), Ontario HIV Treatment Network (grant 1051), Ryerson University, and Public Health Agency of Canada (grant 4500370314). This study and analyses were supported by the Canadian Institutes of Health Research (grant FN-13455). S.M. and D.T. are supported by a Canadian Institutes of Health Research and Ontario HIV Treatment Network New Investigator Award. T.H. is supported by an Ontario HIV Treatment Network Applied HIV Research Chair Award. D.M.M. and N.J.L. are supported by Scholar Awards from the Michael Smith Foundation for Health Research (awards 5209 and 16863). D.G. is supported by a Canada Research Chair in Sexual and Gender Minority Health. N.M. was supported by a Canadian HIV Trials Network postdoctoral fellowship.en_US
dc.identifier.citationWang, L., Moqueet, N., Lambert, G., Grace, D., Rodrigues, R., Cox, J., Lachowsky, N. J., Noor, S. W., Armstrong, H. L., Tan, D. H. S., Burchell, A. N., Ma, H., Apelian, H., Knight, J., Messier-Peet, M., Jollimore, J., Baral, S., Hart, T. A., Moore, D. M., & Mishra, S. (2019). “Population-Level Sexual Mixing According to HIV Status and Preexposure Prophylaxis Use Among Men Who Have Sex With Men in Montreal, Canada: Implications for HIV Prevention.” American Journal of Epidemiology, 189(1), 44-54. DOI: https://doi.org/10.1093/aje/kwz231en_US
dc.identifier.urihttps://doi.org/10.1093/aje/kwz231
dc.identifier.urihttp://hdl.handle.net/1828/13800
dc.language.isoenen_US
dc.publisherAmerican Journal of Epidemiologyen_US
dc.subjectHIV
dc.subjectMSM
dc.subjectPrEP
dc.subjectPrEP-matching
dc.subjectserosorting
dc.subjectsexual mixing patterns
dc.subject.departmentSchool of Public Health and Social Policy
dc.titlePopulation-Level Sexual Mixing According to HIV Status and Preexposure Prophylaxis Use Among Men Who Have Sex With Men in Montreal, Canada: Implications for HIV Preventionen_US
dc.typeArticleen_US

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