Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton

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dc.contributor.authorBoyce, Andrew K.J.
dc.contributor.authorWicki-Stordeur, Leigh E.
dc.contributor.authorSwayne, Leigh Anne
dc.date.accessioned2015-08-25T20:55:25Z
dc.date.available2015-08-25T20:55:25Z
dc.date.copyright2014en_US
dc.date.issued2014-01-30
dc.description.abstractThe roles of pannexin 1 (Panx1) large-pore ion and metabolite channels are becoming recognized in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component network that provides critical structural support, transportation, and scaffolding functions in all cell types. Here we review early work demonstrating the mechanosensitive activation of Panx1 channels, and expand on more recent evidence directly linking Panx1 to the cytoskeleton. Further, we examine the reciprocal regulation between Panx1 and the cytoskeleton, and discuss the involvement of Panx1 in cytoskeletal-regulated cell behaviors. Finally, we identify important gaps in the current knowledge surrounding this emerging Panx1-cytoskeleton relationship.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipNSERC Discovery; NSERC Canadian Graduate Scholarship—Masters; Vanier Canada Graduate Scholarship (NSERC); Heart and Stroke Foundation Partnership for Stroke Recovery; University of Victoria Division of Medical Sciences; University of Victoria Graduate School; Howard E. Petch research scholarship; Edythe Hembroff-Schleicher graduate scholarship; Victoria Foundation Willard and Elva Dawson Fund; Canadian Foundation for Innovation; British Columbia Knowledge Development Funden_US
dc.identifier.citationBoyce, A., Wicki-Stordeur, L. & Swayne, L. 2014, "Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton", FRONTIERS IN PHYSIOLOGY, vol. 5, pp. 27.en_US
dc.identifier.urihttp://dx.doi.org/10.3389/fphys.2014.00027
dc.identifier.urihttp://hdl.handle.net/1828/6550
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.subjectpannexin
dc.subjectPanx1
dc.subjectcytoskeleton
dc.subjectactin
dc.subjectmechanosensitive channels
dc.subjectmechano transduction
dc.subject.departmentDivision of Medical Sciences
dc.subject.departmentSchool of Medical Sciences
dc.subject.departmentDepartment of Biology
dc.subject.departmentDepartment of Biochemistry and Microbiology
dc.titlePowerful partnership: crosstalk between pannexin 1 and the cytoskeletonen_US
dc.typeArticleen_US

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